Characterize the Behavioral Prodromes of Psychotic Disorders in Children With 22q11.2DS Aged From 4 to 13 Years Old
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 80
- Locations
- 2
- Primary Endpoint
- The Screen for child Anxiety Related Emotional Disorders (SCARED)
Study Overview
Brief Summary
The study PremiCeS22 will investigate the prodromal signals at the onset of psychotic disorders of children with 22q11.2 deletion syndrome
Detailed Description
22q11.2DS is one of the most common microdeletion syndromes (1 / 2000-1 / 4000 births) and one of the most robust genetic risk factors for schizophrenia (1 to 2% of cases). Reciprocally, approximately 30% of patients with 22q11.2DS will develop psychotic symptoms in adolescence or early adulthood. It is now well established that children and adults with 22q11.2DS have lower social skills than developing youth. These social dysfunctions could be partly underpinned by alterations in social cognitive processes, and could also be linked to the emergence of psychotic signs or even schizophrenia. However, to our knowledge, no study has investigated the existence of behavioral prodromal signs during the onset of psychotic signs in children with 22q11.2DS. In addition, the origin of social cognitive processes remains to this day little explored.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 4 Years to 13 Years (Child)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Diagnosis of 22q11.2 deletion syndrome or no developmental disease
- •Aged from 4 to 13 years old
- •French language
Exclusion Criteria
- •Diagnosis of intellectual deficiency according to DSM 5 criteria
- •Drug prescribed for somatic condition that could influence cerebral functioning
Outcomes
Primary Outcomes
The Screen for child Anxiety Related Emotional Disorders (SCARED)
Time Frame: Day 1
Scale assessing behavioral prodromes or warning signs of hallucinations in psychotic disorders A psychometric study is then carried out on this questionnaire in order to validate it with parents of children carrying 22q11.2DS.
facial expression recognition task
Time Frame: Day 1
Proportion of correct responses in experimental tasks evaluating gaze direction and facial expression recognition
Secondary Outcomes
- Rey's Tangled Lines Test(Day 1)
- Sustained hearing attention test (Tea-Ch battery)(Day 1)
- NEPSY II battery(Day 1)
- Mean reaction time(Day 1)