Circadian Rhythm of Melatonin in Burns
Completed
- Conditions
- BurnsSleep
- Registration Number
- NCT01596101
- Lead Sponsor
- Shriners Hospitals for Children
- Brief Summary
Evaluate markers and postulated effectors of the endogenous circadian pacemaker in children admitted to the burn intensive care unit.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 86
Inclusion Criteria
- 5-18 years old
Exclusion Criteria
- anoxic brain injury
- preexisting neurological disorder
- pre-existing sleep disorder
- no informed consent or HIPAA release
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method sleep status 48hrs actigraphy, polysomnography
- Secondary Outcome Measures
Name Time Method urinary melatonin every 2 hours for 48 hrs
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link melatonin circadian rhythms to sleep disturbances in pediatric burn patients?
How does melatonin signaling compare to standard-of-care treatments for post-burn sleep disorders in children?
Which biomarkers correlate with circadian melatonin levels in predicting sleep outcomes after severe burns?
What adverse events are associated with circadian melatonin disruption in burn ICU patients and how are they managed?
Are there combination therapies involving melatonin receptor agonists that improve sleep in post-burn recovery?
Trial Locations
- Locations (1)
Shriners Hospital for Children
🇺🇸Cincinnati, Ohio, United States
Shriners Hospital for Children🇺🇸Cincinnati, Ohio, United States