Comparative Genomic Profiling of Lung Adenocarcinoma in Asians and Caucasians: A Propensity Matched Analysis

• Conditions: Adenocarcinoma of Lung

• Registration Number: NCT04692935
• Lead Sponsor: Jun Wang

Brief Summary

Lung adenocarcinomas (LUADs) from Asian ancestry are reported to have different genomic architectures compared with LUADs from Caucasian ancestry. However, due to lack of available cases, few studies controlled the clinical attributes during the comparisons of the genomic alterations. In this study, the investigators will identify Asian LUADs patients who had broad-panel next-generation sequencing (NGS) performed on their primary tumor between January 2018 and December 2019 at the department of thoracic surgery of Peking University People's Hospital. Then, Caucasian LUADs patients who had targeted NGS (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets \[MSK-IMPACT\]) will be identified in the GENIE database, which consists of 6673 primary lung adenocarcinoma samples with clinical annotations. Finally, genomic alterations regarding somatic mutations, copy number variations, fusions, mutational signatures, oncogenic pathways, and therapeutic actionability will be comprehensively compared between these two cohorts after adjusting age, sex, smoking status, and pathologic stage using propensity score matching. This study will elucidate important ancestry differences between Asian and Caucasian lung adenocarcinoma patients.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-12-25
• Study First Submitted QC: 2020-12-31
• Status Verified: 2021-01
• Study Start: 2021-01
• Last Update Submitted: 2021-01-03
• Study First Posted: 2021-01-05
• Last Update Posted: 2021-01-05
• Primary Completion: 2021-07
• Study Completion: 2021-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 450

Inclusion Criteria

• Primary lung adenocarcinoma
• Broad-panel next-generation sequencing
• Asian

Exclusion Criteria

• Inadequate clinicopathological information
• Low-quality next-generation sequencing

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Oncoprint of somatic mutations	July 2021	Association between genomic features and race
Copy number variations (CNVs)	July 2021	CNVs analysis by race
Mutational signatures	August 2021	Analysis of mutational signatures by race
Oncogenic pathways	September 2021	Analysis of oncogenic pathways by race
Therapeutic actionability	October 2021	Analysis of actionable alterations by race