Prevalence of Gastric Motor Dysfunction and Upper GI Symptoms in Gastric Antral Vascular Ectasias
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- Mayo Clinic
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Nepean Dyspepsia Index
研究概览
简要总结
The researchers are trying to find out more about Gastric Antral Vascular Ectasia (GAVE). This is a condition that affects the blood vessels in the stomach, leading to their enlargement and possible bleeding. It can also cause symptoms such as abdominal pain and nausea. By participating in this study, you will help us learn how often these symptoms occur and how they relate to stomach functioning.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients >18 years of age with endoscopic evidence of Gastric Antral Vascular Ectasia.
- •Willingness to participate in the study
- •Capacity to provide informed consent.
- •No evidence of organic, systemic, or metabolic disease (e.g. diabetes mellitus) to explain the symptoms on routine investigations
排除标准
- •Patients with transfusion dependent blood loss.
- •Patients with severe decompensated liver disease.
- •Patients with end stage renal disease.
- •Presence of other diseases (structural or metabolic) which could interfere with interpretation of the study results.
- •Pregnant or lactating women.
- •Patients who have not had a CBC and differential blood draw completed within the last six months.
- •Current heavy alcohol use.
研究组 & 干预措施
Cirrhosis or Chronic Kidney Disease With Gastric Antral Vascular Ectasia
Patients with Gastric Antral Vascular Ectasia with cirrhosis or chronic kidney disease will undergo a gastric emptying breath test. This test is designed to show how quickly the stomach empties solids by measuring labeled carbon dioxide in a patient's breath.
干预措施: Gastric Emptying Breath Test (Diagnostic Test)
Cirrhosis or Chronic Kidney Disease Without Gastric Antral Vascular Ectasia
Patients without Gastric Antral Vascular Ectasia with cirrhosis or chronic kidney disease will undergo a gastric emptying breath test. This test is designed to show how quickly the stomach empties solids by measuring labeled carbon dioxide in a patient's breath.
干预措施: Gastric Emptying Breath Test (Diagnostic Test)
结局指标
主要结局
Nepean Dyspepsia Index
时间窗: baseline
The Nepean Dyspepsia Index is a 10-item questionnaire that measures dyspepsia problems. Each item is scored from 1-5. 1 = Not at all, 5 = Extremely. Total scores range from 10 - 50, lower scores indicate less dyspepsia problems, higher scores indicate more dyspepsia problems.
Leuven Postprandial Distress Scale
时间窗: baseline
The Leuven Postprandial Distress Scale is an 8-item questionnaire that measures symptoms of dyspepsia. Each item is scored from 1-5. 1 = Absent, 5 = very severe. Total scores range from 0-40 Lower scores indicate less or no symptoms of dyspepsia, higher scores indicate more symptoms of dyspepsia.
Abridged Bowel Disease Questionnaire
时间窗: baseline
The Abridged Bowel Disease Questionnaire is a 14-item questionnaire that measures Bowel Disease symptoms. Each item is scored as yes or no. Scores answering yes indicate more bowel disease, and scores answering no indicate less or no bowel disease.
Bowel Disease Screen Questionnaire
时间窗: Baseline
the Bowel Disease Screen Questionnaire is a 20 item questionnaire that measures stomach and bowel disease symptoms. Each item is scored from 1-5. 1=not at all, 5=Extremely. Total scores range from 10-95.
次要结局
- GEBT Breath Test(6 Hours)
研究者
Xiao Jing (Iris) Wang
Principal Investigator
Mayo Clinic