Evaluating fibres on gut health in Irritable Bowel Syndrome

Not Applicable

• Conditions: Gut Diseases; Irritable Bowel Syndrome; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12619000691145
• Lead Sponsor: Monash University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-05-08
• Study Completion: 2020-10-26
• Last Update Posted: 12 July 2021

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

* IBS defined by ROME IV diganostic criteria.
Potential participants not been formally diagnosed with IBS but presenting with the clinical features of the condition (i.e. recurrent abdominal pain and associated changes to bowel habit) will be referred to an appropriate medical doctor (either study gastroenterologist or their general practitioner) for formal diagnosis based on ROME IV criteria.

* Currently symptomatic
Eligible participants will then be invited to undertake screening to evaluate their IBS symptoms over five days. Symptoms will be assessed via a 100-mm VAS, where 0 mm indicates no symptoms and 100 mm represents the worst symptoms experienced. Participants whose scores are at least 30 mm for overall symptoms on the VAS will be included in the study.

Exclusion Criteria

* Consumption of a special diet (i.e. low FODMAP, vegan diet).
* Significant comorbidities (i.e. diabetes, chronic kidney disease).
* Use of antibiotic therapies in the month preceding study commencement.
* Consumption of prebiotics and probiotics in the month preceding study commencement.
* Use of medication that potentially affects GI transit (i.e. hypomotility agents, laxatives).
* Pregnancy or planning pregnancy.
* Current smoker.
* Unable to give written informed consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total faecal output (total weight in grams).[Total faecal output will be collected over the final five days of the baseline period and each dietary intervention period.]