Preemptive morphine suppository for postoperative pain relief after laparoscopic cholecystectomy

Not Applicable

• Conditions: k80; Postcholecystectomy syndrome.; Disorders of gallbladder, biliary tract and pancreas; k91.5

• Registration Number: IRCT2015010620588N1
• Lead Sponsor: Isfahan University of Medical Sciences

Brief Summary

ABSTRACT:<br /> Background: Many patients experience considerable pain after cholecystectomy, so there is no general agreement on Effective pain control. Rectal morphine suppositories are one of the newly released morphine forms. The aim of this study was assessing the effect of suppository morphine on postoperative pain relief after laparoscopic cholecystectomy.<br /> Materials and methods: <br /> Seventy patients scheduled for elective laparoscopic cholecystectomy under general anesthesia, were randomly allocated to two groups according to the drug used for postoperative analgesia: Group MS (morphine suppository-10mg) and Group PS(placebo suppository). Pain intensity based on visual analogous scale (VAS) and opioid consumption were assessed 30, 60 minutes and 2,4,8,16,24 hours after arrival of the patient to the recovery room.<br /> RESULTS:VAS scores were significantly lower in MS group compared With PS group from 30 minutes after arrival to recovery room till 16 hours postoperatively(p

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

inclusion criteria: ASA physical status I-II? candidates for elective laparoscopic cholecystectomy under general anesthesia; age span from 18 to 65 years; body mass index (BMI) less than 30; lack of sensitivity to morphine and or similar compounds; lack of addiction to opioids; and no renal liver failure.
exclusion criteria:ASA>2; Any event that leads to changing the Anesthesia or surgery technique.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain. Timepoint: On arrival to recovery room, and then 30, 60, minutes and 2, 4, 8, 16, 24 hours after that. Method of measurement: VAS SCORE.

Secondary Outcome Measures

Name	Time	Method
Decreasing of the total dose of analgesics. Timepoint: From 30 minutes after recovery to 24 hours after surgery. Method of measurement: measurement of total analgesic drugs used.;Hemodynamic stability. Timepoint: From 30 minutes after recovery to 24 hours after surgery. Method of measurement: By pulse oxymetery; non invasive blood pressure monitoring;.