Debridement, Antibiotics and Implant Retention in Early Periprosthetic Joint Infection: A Retrospective Cohort Study

Danderyd Hospital1 site in 1 country51 target enrollmentJanuary 2013

ConditionsDirect Infection of Hip- and Knee Arthroplasty

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Direct Infection of Hip- and Knee Arthroplasty
Sponsor: Danderyd Hospital
Enrollment: 51
Locations: 1
Primary Endpoint: Successful treatment
Status: Completed
Last Updated: 12 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Introduction: Periprosthetic joint infection (PJI) is a common cause for reoperation after knee and hip arthroplasty surgery. Debridement, antibiotics and implant retention (DAIR) is recommended in early infections (< 4 weeks) and stable implants. Aims: To define the success rate of DAIR in early infections and to identify predictors for success. Material and methods: In a retrospective cohort study we included patients with hip- or knee arthroplasties reoperated for an early PJI at Danderyd Hospital 2007-2012. Logistic regression analysis was used to identify risk factors affecting success rate. Primary outcome variable was the success of the DAIR treatment. Secondary outcome variable vas risk factors for treatment failure.

Registry

clinicaltrials.gov

Start Date

January 2013

End Date

June 2013

Last Updated

12 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Danderyd Hospital

Responsible Party

Principal Investigator

Olof Skoldenberg

MD, PhD

Danderyd Hospital

Eligibility Criteria

Inclusion Criteria

•Patients treated with DAIR for early postoperative periprosthetic joint infection after knee- or hip arthroplasty surgery (\<4-6 weeks postoperatively) at our institution between 2007-01-01 and 2012-12-01.

Exclusion Criteria

•Chronic or late presenting periprosthetic joint infection (\>6 weeks postoperatively), acute hematogenous periprosthetic joint infection, when the periprosthetic joint infection diagnosis criteria according to American Musculoskeletal Infection Society (MSIS) 2011 definition of PJI definitions were not fulfilled and when the initial surgical treatment was with other treatment protocol than DAIR including one-stage revision and two -stage revision

Outcomes

Primary Outcomes

Successful treatment

Time Frame: 6 year

The success rate, in terms of infection eradication without additional surgical methods, of debridement, antibiotics and implant retention in early postoperative periprosthetic joint infection..