Hypodontia and Ovarian Cancer

• Conditions: Hypodontia; Breast Cancer; Colon Cancer; Ovarian Cancer

• Registration Number: NCT01470235
• Lead Sponsor: University of Aarhus

Brief Summary

The purpose of this project is to examine whether the risk of developing ovarian cancer is increased in Danish women with congenital missing teeth as a result of their failure to develop (hypodontia). Should this prove to be the case, these women could be offered regular clinical controls and prophylactic removal of their ovaries when menopause enters and the ovaries are no longer functional (producing hormones).

If there is a connection between congenital hypodontia and the development of different types of cancer, the investigators will perform a genetic screening in families with increased risk of cancer and hypodontia for changes in relevant genes, based on the current literature. The investigators hereby search for new genes, which in a changed form leads to an increased risk of cancer and thereby enables us to perform genetic screening in risk families.

Detailed Description

Not available

Basic Information
|
Recruitment & Eligibility
|
Study & Design
|
Trial Locations

Study Timeline

• Study Start: 2011-09
• Study First Submitted: 2011-11-09
• Study First Submitted QC: 2011-11-09
• Study First Posted: 2011-11-11
• Status Verified: 2013-10
• Last Update Submitted: 2013-10-31
• Last Update Posted: 2013-11-01
• Primary Completion: 2014-09
• Study Completion: 2015-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 200

Inclusion Criteria

• confirmed suspicion of ovarian cancer.

Read More

Exclusion Criteria

• suspicion of ovarian cancer disproved.

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence rates of hypodontia in women with ovarian cancer	one year

Secondary Outcome Measures

Name	Time	Method
Prevalence rates of hypodontia in patients with a known risk for epithelial cancer	one year
Genetic causes for hypodontia and ovarian cancer	two years

Trial Locations

Locations (2)

Aarhus University Hospital; 🇩🇰 Skejby, Aarhus, Denmark

Copenhagen University Hospital; 🇩🇰 Copenhagen Ø, Copenhagen, Denmark