Diagnostic Performance of 18-FDG PET-CT Scores for the Diagnosis of Polymyalgia Rheumatica

Not yet recruiting

• Conditions: Inflammatory Rheumatism; 18-FDG; Positron-emission Tomography

• Registration Number: NCT06558357
• Lead Sponsor: University Hospital, Brest

Brief Summary

Study of the diagnostic performance of 18-FDG PET scores in Polymyalgia rheumatica and comparaison with others inflammatories diseases.

Detailed Description

Polymyalgia Rheumatica is difficult to diagnostic because symptoms are non specific and many diseases can be differential diagnosis (cancer, infections, others rheumatisms...).

PET-CT is more often used to help for diagnostic of inflammatory disease, and particularly inflammatory rheumatism.

Some scores have been described to harmonize the diagnosis of Polymyalgia rheumatica.

The aim of this study is to evaluate the diagnostic performance of 18-FDG PET scores in Polymyalgia rheumatica and compared with others inflammatories diseases such as ankylosing spondylarthritis.

This is a multicentric retrospective study.

Study Timeline

• Status Verified: 2024-06
• Study First Submitted: 2024-08-13
• Study First Submitted QC: 2024-08-14
• Study First Posted: 2024-08-16
• Last Update Submitted: 2024-08-19
• Last Update Posted: 2024-08-20
• Study Start: 2024-09-01
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 210

Inclusion Criteria

• Having 18-FDG PET-CT between 2012 and 2024
• Diagnosis of inflammatory rheumatism by specialist doctor
• Adult without opposition to use there data for research
• Affiliate to social security system

Exclusion Criteria

• Refusal participation
• Patient under juridic protection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diagnostic performance of 18-FDG PET scores for diagnostic of Polymyalgia rheumatica.	up to 9 months	Evaluation of the metabolism of mains joints compared to liver. Calculation of different scores described in literature.

Secondary Outcome Measures

Name	Time	Method
Comparaison of scores with clinical, biological and radiological data.	up to 9 months	Search for correlation between scores and symptoms, blood test or CT/MRI exams.
Analysis of SUV and visual fixation of mains joints.	up to 9 months	Measure of SUV of mains joints and evaluation of the fixation compared to liver.
Diagnostic performance of 18-FDG PET scores for diagnostic of others inflammatory rheumatism.	up to 9 months	Evaluation of the precedent scores for diagnosis of others rheumatisms. Creation of others scores if some joints seem to be interesting.

Trial Locations

Locations (1)

Chu Brest; 🇫🇷 Brest, France