CO2 Rebreathing by a Partial Rebreathing Mask as a Treatment of Chronic Idiopathic Hyperventilation - a Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- Blood gas and acid/base status
研究概览
简要总结
Background: Chronic Idiopathic Hyperventilation (CIH) is a form of dysfunctional breathing which has proven hard to treat effectively. The investigators hypothesised that by periodically inducing normocapnia over several weeks, it would be possible to raise the normal resting level/set point of CO2 and achieve a reduction of symptoms.
Methods: Six CIH patients were treated two hours a day for four weeks with a novel breathing mask. The mask was used to induce normocapnia in these chronically hypocapnic patients.
Capillary blood gases (PcCO2, pH, Standard Base Excess (SBE) etc.) were measured at baseline and once each week at least three hours after mask use, as well as spirometric values, breath holding tolerance and hyperventilation symptoms as per the Nijmegen Questionnaire (NQ),.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chronic idiopathic hyperventilation, i.e.:
- •PCO2 level below 4.7 kPa AND
- •SBE value more negative than -1.0
排除标准
- •Oxygen saturation of 95% or lower at rest
研究组 & 干预措施
Partial Rebreathing Mask
A novel membrane breathing mask which facilitates a partial rebreathing of expired gas (thereby raising systemic CO2), while allowing a diffusion of oxygen from the atmosphere to the user, through the membranes.
干预措施: Partial Rebreathing Mask (Device)
结局指标
主要结局
Blood gas and acid/base status
时间窗: Once every week in the treatment period of four weeks
pH, PCO2, PO2, Standard Base Excess
次要结局
- Hyperventilation symptoms(once a week)
- Breath Hold Tolerance(once a week)
- Spirometric values(once a week)