The influence of breathing techniques and exposure to cold on inflammation during human endotoxemia, an explorative study - EXPOCO

Intensive Care0 个研究点目标入组 48 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

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•Prior experience with any of the elements of the intervention developed by Hof;Prior experience with other breathing, meditation, or cold exposure techniques;Use of any medication;Smoking;History of asthma;Previous spontaneous vagal collapse;History of atrial or ventricular arrhythmia;(Family) history of myocardial infarction or stroke under the age of 65 years;Cardiac conduction abnormalities on the ECG consisting of a 2nd degree atrioventricular block or a complex bundle branch block;Hypertension (defined as RR systolic > 160 or RR diastolic > 90);Hypotension (defined as RR systolic < 100 or RR diastolic < 50);Renal impairment (defined as plasma creatinin >120 µmol/l);Liver enzyme abnormalities;Medical history of any disease associated with immune deficiency;CRP > 20 mg/L, WBC > 12x109/L, or clinically significant acute illness, including infections, within;4 weeks before endotoxin administration;Participation in a drug trial or donation of blood 3 months prior to the LPS challenge;Use of recreational drugs within 7 days prior to endotoxemia experiment day;Recent hospital admission or surgery with general anaesthesia (<3 months)

发起方

Intensive Care