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临床试验/NCT01475812
NCT01475812已完成不适用

Daily Activities Are Sufficient to Induce Dynamic Pulmonary Hyperinflation and Dyspnea in Chronic Obstructive Pulmonary Disease Patients

Federal University of São Paulo1 个研究点 分布在 1 个国家目标入组 19 人开始时间: 2007年3月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
19
试验地点
1
主要终点
Inspiratory capacity variability within the accomplishment of activities of daily living in COPD patients.

研究概览

简要总结

Introduction: Chronic obstructive pulmonary disease is a condition characterized by airflow limitation usually progressive and associated with inflammatory response of lung noxious particles. During a physical activity chronic obstructive pulmonary disease patients may develop dynamic pulmonary hyperinflation, increased dyspnea perception and decreased activity performance. The investigators hypothesize that some specific activities of daily living induce dynamic pulmonary hyperinflation in COPD patients. Objective: To measure dynamic lung hyperinflation and its influence in dyspnea perception in moderate and severe chronic obstructive pulmonary disease patients after activities of daily living. Methods: The investigators measured inspiratory capacity, dyspnea sensation, peripheral oxygen saturation, heart rate and respiratory rate in 19 chronic obstructive pulmonary disease (COPD) patients. These measurements were taken at rest and after daily living activities (such as going up and down a set of stairs, going up and down a ramp and sweeping and mopping a room).

研究设计

研究类型
Observational
时间视角
Cross Sectional

入排标准

年龄范围
50 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • COPD patients diagnosed with moderate to very severe airway obstruction according to GOLD classification (9)
  • clinical stability with no clinical exacerbation during the previous 30 days prior to the beginning of the study and to sign an informed consent form

排除标准

  • Inability to perform the slow vital capacity maneuver
  • excessive perceived dyspnea during the test
  • arterial oxyhemoglobin saturation (SpO2) lower than 80% during activities and/or need of oxygen supplementation

结局指标

主要结局

Inspiratory capacity variability within the accomplishment of activities of daily living in COPD patients.

时间窗: 3 months

次要结局

未报告次要终点

研究者

发起方
Federal University of São Paulo
申办方类型
Other
责任方
Principal Investigator
主要研究者

Antonio A.M. Castro

Dr.

Federal University of São Paulo

研究点 (1)

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