St. John's Wort Photodynamic Therapy

Not Applicable

Completed

• Conditions: Acne
• Interventions: Procedure: PDT

• Registration Number: NCT05073211
• Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary

The investigators aimed to evaluated the efficacy and safety of SJW-PDT compared to indole-3-acetic acid (IAA)-PDT in the treatment of acne. The investigators also investigated the skin rejuvenating effects of SJW-PDT.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-06-01
• Primary Completion: 2021-04-01
• Status Verified: 2021-09
• Study Completion: 2021-09-01
• Study First Submitted: 2021-09-17
• Study First Submitted QC: 2021-09-28
• Last Update Submitted: 2021-09-28
• Study First Posted: 2021-10-11
• Last Update Posted: 2021-10-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

• patients with mild to moderate facial acne
• between 25 and 60 years old

Exclusion Criteria

• history of oral retinoid treatment with the past 6 months
• history of oral antibiotics, topical acne treatment, or skin rejuvenation treatment such as lasers and chemical peeling within the month before the start of the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
SJW-PDT	PDT	Participants were randomized to receive either the SJW extract or IAA on each split-face. The SJW extract (DR-Light complexTM; Genicos Co., Ltd, Cheongju, Korea) consisted of 70% 1, 3-butylene glycol, and 0.1% hypericin as active ingredients. After cleansing the face gently, participants applied 1.5 ml of 0.5% SJW extract on one half of the face and 1.5 ml of 0.015% IAA (AC gel®; Wellskin, Seoul, Korea) on the other half of the face for 10 minutes under occlusion.
IAA-PDT	PDT	Participants were randomized to receive either the SJW extract or IAA on each split-face. The SJW extract (DR-Light complexTM; Genicos Co., Ltd, Cheongju, Korea) consisted of 70% 1, 3-butylene glycol, and 0.1% hypericin as active ingredients. After cleansing the face gently, participants applied 1.5 ml of 0.5% SJW extract on one half of the face and 1.5 ml of 0.015% IAA (AC gel®; Wellskin, Seoul, Korea) on the other half of the face for 10 minutes under occlusion.

Primary Outcome Measures

Name	Time	Method
acne lesions	1 and 4 weeks after the last treatment	change in the number of acne lesions after the treatment

Secondary Outcome Measures

Name	Time	Method
sebum secretion rate (μg/cm2)	1 and 4 weeks after the last treatment	Sebum secretion rate was measured with Sebumeter SM 815®.

Trial Locations

Locations (1)

Seoul National University Bundang Hospital; 🇰🇷 Seongnam, Korea, Republic of