NCT01935323已完成不适用
High Intensity Interval Versus Continuous Moderate Intensity Training: Maximizing the Benefits of Exercise in Overweight Adolescents.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Body Composition as measured by DXA
研究概览
简要总结
6-week, single site, two parallel arm, randomized, controlled trial comparing the effectiveness of a High Intensity Interval Training (HIIT) versus a continuous Moderate Intensity Training (MIT) program on cardiovascular and metabolic health outcomes in overweight adolescent males. HIIT training may be a potent time-efficient strategy to induce similar metabolic and cardiovascular adaptations typically associated with MIT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 17 Years 至 22 Years（Child, Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Ages 17-22
- •BMI (25.0 - 35.0 kg/m2)
- •Interested in improving health and fitness
排除标准
- •Weight loss or gain of >10% of body weight in the past 6 months for any reason.
- •Currently taking medication that suppresses or stimulates appetite.
- •History of prior surgical procedure for weight control or liposuction.
- •Current smoker.
- •Any major disease, including:
- •Active cancer or cancer requiring treatment in the past 2 years (except nonmelanoma skin cancer).
- •Active or chronic infections, including self-reported HIV positivity and active tuberculosis.
- •Diagnosed heart conditions.
- •Uncontrolled hypertension: systolic blood pressure 160 mm Hg or diastolic blood pressure 95 mm Hg on treatment.
- •Gastrointestinal disease, including self-reported chronic hepatitis or cirrhosis, any episode of alcoholic hepatitis or alcoholic pancreatitis within past year, inflammatory bowel disease requiring treatment in the past year, recent or significant abdominal surgery (e.g., gastrectomy).
- •Diagnosed diabetes (type 1 or 2), fasting impaired glucose tolerance (blood glucose 118 mg/dL), or use of any anti-diabetic medications.
- •Conditions or behaviors likely to effect the conduct of the trial: unable or unwilling to give informed consent; unable to communicate with the pertinent clinic staff; unwilling to accept treatment assignment by randomization; current or anticipated participation in another intervention research project that would interfere with the intervention offered in the trial; likely to move away from participating clinics before trial completed; unable to walk 0.25 mile in 10 minutes.
- •Currently taking antidepressant, steroid, or thyroid medication, unless dosage is stable (no change for 6 months).
- •Any active use of illegal or illicit drugs.
- •Excessive alcohol intake defined as an average consumption of 3 or more alcohol containing beverages daily.
- •Unwilling to limit alcohol intake to ≤2 drink per day (one drink = 4 oz. wine, 12 oz. beer, or ½ shot of liquor).
- •Current exerciser (>30 min organized exercise per week).
- •Indication of unsuitability of current health for exercise protocol (PARQ).
- •Any other conditions which, in opinion of the investigators, would adversely affect the conduct of the trial.
结局指标
主要结局
Body Composition as measured by DXA
时间窗: Baseline and 6 weeks
次要结局
- Ghrelin(Baseline and 6 weeks)
- Adiponectin(Baseline and 6 weeks)
- HDL Cholesterol(Baseline and 6 weeks)
- Body Weight(Baseline and 6 weeks)
- Blood Pressure(Baseline and 6 weeks)
- Peak uptake of volume of oxygen(Baseline and 6 weeks)
- Wingate Cycle test(Baseline and 6 weeks)
- Body Mass Index(Baseline and 6 weeks)
- LDL Cholesterol(Baseline and 6 weeks)
- Triglycerides(Baseline and 6 weeks)
- Insulin(Baseline and 6 weeks)
- Leptin(Baseline and 6 weeks)
- Glucose(Baseline and 6 weeks)
- Free living energy expenditure as measured by accelerometer(Baseline and 6 weeks)
- PYY(Baseline and 6 weeks)
- Protein Carbonyls(Baseline and 6 weeks)
- Quality & satisfaction with life(baseline & 6 weeks)
- Rate of perceived exertion during exercise via Borg Scale(baseline and 6 weeks)
- IL-6(Baseline and 6 weeks)
- TNF-alpha(Baseline and 6 weeks)
- Appetite/satiety measures(baseline & 6 weeks)
- 24-hour dietary recall(pre-baseline, baseline, 6 weeks)
- Self Motivation Inventory(baseline and 6 weeks)
- Total antioxidant capacity(Baseline and 6 weeks)
- Profile of Mood States(baseline & 6 weeks)
研究者
David Allison, Phd
Principal Investigator
University of Alabama at Birmingham
研究点 (2)
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