Effect of Daytime Variation on Postoperative Hyperalgesia Induced by Opioids

Completed

• Conditions: Postoperative Hyperalgesia
• Interventions: Drug: Remifentanil

• Registration Number: NCT05234697
• Lead Sponsor: The Second Affiliated Hospital of Chongqing Medical University

Brief Summary

To explore the effect of daytime variation on postoperative hyperalgesia induced by opioids. Patients receiving endoscopy surgery under general anesthesia during 08:00-12:00(morning group, n=30) and 14:00-18:00(afternoon group, n=30) using remifentanil for anesthesia maintenance were respectively included. Postoperative hyperalgesia at PACU and 24 hours after surgery were assessed through mechanical pain measurement. Comparative analysis of postoperative hyperalgesia levels, pain and analgesic requirements between morning group and afternoon group were performed.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-01-12
• Study First Submitted: 2022-01-12
• Study First Submitted QC: 2022-02-08
• Study First Posted: 2022-02-10
• Primary Completion: 2022-05-20
• Study Completion: 2022-05-20
• Status Verified: 2022-12
• Last Update Submitted: 2022-12-27
• Last Update Posted: 2022-12-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• American Society of Anesthesiologists classification I-II
• Abdominal endoscopy surgery
• Estimated surgery duration 1-2h
• Right handedness
• Voluntarily receive postoperative intravenous controlled analgesia

Exclusion Criteria

• Heavy smoking or alcohol dependence
• Puerpera or lactation women
• History of chronic pain
• Analgesic use within one month before surgery
• Allergy to opioids
• Can not follow with the study procedure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Morning group	Remifentanil	Surgery performed during 08:00 to 12:00
Afternoon group	Remifentanil	Surgery performed during 14:00 to 18:00

Primary Outcome Measures

Name	Time	Method
Postoperative hyperalgesia when discharged from postanesthesia care unit	from the 30 minutes before the surgery until to the time when discharged from postanesthesia care unit, assessed up to about 2 hours	The ratio of pressure pain threshold when discharged from PACU compare to before surgery

Secondary Outcome Measures

Name	Time	Method
Activity of plasma nonspecific esterase	from 30 minutes before the surgery until to the time after stop infusion of remifentanil, , assessed up to about 2 hours	Determined by laboratory detection
Postoperative hyperalgesia at 24 hours after surgery	from the 30 minutes before the surgery until to 24 hours after surgery	The ratio of pressure pain threshold at 24 hours after surgery compare to before surgery
Postoperative pain intensity	from the time when the surgery was completed until to 24 hours after surgery	Pain intensity was assessed by numerical rating scale (0-10, 0 represents painless; 10 represents intolerable pain)
Plasma concentration of remifentanil and sufentanil	from 30 minutes before the surgery until to the time after stop infusion of remifentanil, assessed up to about 2 hours	Determined by Elisa test
Postoperative analgesic requirements	from the time when the surgery was completed until to 24 hours after surgery	Analgesic requirements was assessed by recording the volume of patient controlled analgesia pump

Trial Locations

Locations (1)

Department of Anesthesiology, The Second Affiliated Hospital, Chongqing Medical University; 🇨🇳 Chongqing, Chongqing, China