Sleep and Circadian Contributions to Nighttime Blood Pressure
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 1,427
- 试验地点
- 1
- 主要终点
- Change in Melatonin
研究概览
简要总结
Broadly, this study (SCN-BP) seeks to examine sleep and circadian factors that contribute to blood pressure levels at night.
详细描述
SCN-BP is imbedded in a parent grant titled "Improving the Detection of Hypertension (IDH-MEGA)" and examines a variety of sleep (e.g., sleep duration, timing, and the presence of sleep disorder) and circadian factors in Aims 1 and 2. In Aim 3, the investigators will conduct a 30-hour constant routine protocol to directly examine endogenous circadian and blood pressure rhythms. Aims 1 and 2 are purely observation. The study design design described below pertains the intervention piece of this study (Aim 3).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participant in the parent grant (IDH-MEGA)
排除标准
- 未提供
研究组 & 干预措施
Constant Routine Protocol
Participants complete a 30-hour constant routine protocol to directly examine markers of endogenous circadian rhythms. In a constant routine protocol, participants remain in a dimly lit room (<10 lux), in a semi-recumbent posture, remain awake, and consume iso-caloric snacks. Saliva samples are collected and core body temperature and blood pressure are measured.
干预措施: Constant Routine Protocol (Other)
结局指标
主要结局
Change in Melatonin
时间窗: Hourly samples obtained over 30 hours
Melatonin levels obtained from saliva samples
Change in Core body temperature
时间窗: Continuous measurements over 30 hours
Core body temperature
次要结局
- Change in Blood pressure(Measurements obtained every 30 minutes over 30 hours)
研究者
Stephen Justin Thomas, PhD
Assistant Professor
University of Alabama at Birmingham