Sleep and Circadian Contributions to Nighttime Blood Pressure
Overview
- Phase
- Not Applicable
- Intervention
- Constant Routine Protocol
- Conditions
- Sleep
- Sponsor
- University of Alabama at Birmingham
- Enrollment
- 1427
- Locations
- 1
- Primary Endpoint
- Change in Melatonin
- Status
- Enrolling By Invitation
- Last Updated
- 3 months ago
Overview
Brief Summary
Broadly, this study (SCN-BP) seeks to examine sleep and circadian factors that contribute to blood pressure levels at night.
Detailed Description
SCN-BP is imbedded in a parent grant titled "Improving the Detection of Hypertension (IDH-MEGA)" and examines a variety of sleep (e.g., sleep duration, timing, and the presence of sleep disorder) and circadian factors in Aims 1 and 2. In Aim 3, the investigators will conduct a 30-hour constant routine protocol to directly examine endogenous circadian and blood pressure rhythms. Aims 1 and 2 are purely observation. The study design design described below pertains the intervention piece of this study (Aim 3).
Investigators
Stephen Justin Thomas, PhD
Assistant Professor
University of Alabama at Birmingham
Eligibility Criteria
Inclusion Criteria
- •Participant in the parent grant (IDH-MEGA)
Exclusion Criteria
- Not provided
Arms & Interventions
Constant Routine Protocol
Participants complete a 30-hour constant routine protocol to directly examine markers of endogenous circadian rhythms. In a constant routine protocol, participants remain in a dimly lit room (\<10 lux), in a semi-recumbent posture, remain awake, and consume iso-caloric snacks. Saliva samples are collected and core body temperature and blood pressure are measured.
Intervention: Constant Routine Protocol
Outcomes
Primary Outcomes
Change in Melatonin
Time Frame: Hourly samples obtained over 30 hours
Melatonin levels obtained from saliva samples
Change in Core body temperature
Time Frame: Continuous measurements over 30 hours
Core body temperature
Secondary Outcomes
- Change in Blood pressure(Measurements obtained every 30 minutes over 30 hours)