Effectiveness of low-dose olanzapine for prevent postoperative nausea and vomiting after gynecologic laparoscopic surgery

Phase 4

Recruiting

• Conditions: Patient who undergoes gynecologic laparoscopic surgery; Gynecologic laparoscopic surgery Postoperative nausea vomiting Low-dose olanzapine

• Registration Number: TCTR20221027005
• Lead Sponsor: Faculty of Medicine Ramathibodi Hospital, Mahidol University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-27
• Study Completion: 2024-03-26
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 180

Inclusion Criteria

1. Patient who undergoes elective gynecologic laparoscopic surgery
2. The American Society of Anesthesiologists (ASA) Physical Status Classification I-III
3. Patient with age between 18-65
4.Patient who accept to be included in the project.

Exclusion Criteria

1. Patient who have psychological symptoms.
2. Patient with pregnancy and breast feeding
3. Patient with morbid obesity
4. Patient with abnormal EKG (QT prolong ,Torsades de pointes)
5. Patient who have contraindication of olanzapine (drug allergy,parkinson disease,dementia)
6. Patient with severe metabolic disease
7. Patient who have indication for nasogastric tube after surgery
8. Patient with history of chemotherapy within 4 weeks before surgery
9. Patient who refuse to be included in the project.

Study & Design

• Study Type: Interventional
• Study Design: Not specified