The Effects of a Moderate Intensity Training Program Versus a High Intensity Training Program on Central Pain Processing
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Conditioned pain modulation
研究概览
简要总结
Previous studies have shown that healthy individuals who take more steps per day and who spend more time on moderate- to vigorous-intensity activities exhibit better pain inhibition and less pain facilitation. Furthermore, exercise training (i.e., exercise performed over a number of sessions) can result in reduced pain sensitivity (increased pressure pain threshold). However, the optimal exercise prescription required to achieve pain sensitivity reduction is currently unclear. The next step is to determine experimentally whether increasing physical fitness will lead to positive effects on central pain processing (i.e., pain sensitivity, pain modulation, spinal nociception). The aim of this study is to examine the effects of two exercise programs on central pain processing in healthy sedentary individuals. In case of positive effects, this would provide a rationale for the future to investigate this in chronic pain patients with impaired pain modulation.
详细描述
Objectives:
Since research on the effects of chronic exercise interventions on pain modulation is scarce and since there is no optimal exercise prescription to reduce pain sensitivity, the effects of a moderate intensity training (MIT) program versus a high intensity training (HIT) program on central pain processing will be examined in healthy sedentary individuals.
Study population:
Thirty healthy sedentary adults between 18 and 55 years of age and with a body mass index (BMI) between 20 and 25 kg/cm² will be recruited. Sedentary is defined as "having a sedentary job and performing less than three hours of moderate physical activity per week". Moderate physical activity is defined as "an activity that requires at least three times the amount of passively expended energy". The sample size was calculated based on a similar previously conducted study.
Study Protocol:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age between 18 and 55 years
- •BMI between 20 and 25 kg/m²
- •Dutch-speaking
- •sedentary job and performing less than 3 hours of moderate physical activity per week
排除标准
- •current pain complaints or other (medical and/or psychological) health problems
- •history of serious pain complaints or (medical and/or psychological) health problems
- •history of serious conditions (e.g. cancer, cardiovascular disease, epilepsy, diabetes, depression, etc.)
- •being pregnant
- •pregnant in the past 12 months
- •currently breastfeeding
研究组 & 干预措施
Moderate intensity training program
干预措施: Moderate intensity training program (Other)
High intensity training program
干预措施: High intensity training program (Other)
结局指标
主要结局
Conditioned pain modulation
时间窗: Change from baseline (T1) at 1 week after intervention (T2)
A conditioned pain modulation paradigm will be performed in which the measurement of the pressure pain threshold (= test stimulus) will be repeated on the dominant body side during (at minute two) and two minutes after immersion of the non-dominant hand in a warm water bath (= conditioning stimulus) of 45.5°C for six minutes.
Pressure pain threshold
时间窗: Change from baseline (T1) at 1 week after intervention (T2)
Pressure algometry will be performed using a digital algometer to determine the pressure pain threshold bilaterally on the muscle belly of the extensor carpi radialis and the rectus femoris.
Exercise-induced hypoalgesia
时间窗: Change from baseline (T1) at 1 week after intervention (T2)
To evaluate exercise-induced hypoalgesia, the pressure pain threshold measurements will be repeated before (bilaterally) and after (on the dominant body side) a submaximal exercise test (Aerobic Power Index test) performed on an electrically braked bicycle ergometer.
Nociceptive flexion reflex - threshold
时间窗: Change from baseline (T1) at 1 week after intervention (T2)
The nociceptive flexion reflex will be elicited by performing transcutaneous electrical nerve stimulation of the sural nerve of the dominant leg in its retromalleolar path using a bar electrode. The elicitation of the NFR will be evaluated by measuring the involuntary contraction of the ipsilateral biceps femoris, which will be recorded using electromyography.
Nociceptive flexion reflex - temporal summation
时间窗: Change from baseline (T1) at 1 week after intervention (T2)
Five 1ms rectangular wave pulse train will be administered 3 times at a frequency of 2 Hz at a constant stimulation intensity. This procedure will be repeated 5 times.
次要结局
- Step count(During 10-week intervention program)
- Resting heart rate(Baseline (T1))
- International physical activity questionnaire(Change from baseline (T1) at 1 week after intervention (T2))
- Moderate physical activity(Change from baseline (T1) at 1 week after intervention (T2))
- Hospital anxiety and depression scale(Baseline (T1))
- Blood pressure(1 week after intervention)
- Sociodemographic and health-related characteristics(Baseline (T0))
- Sedentary behavior(Change from baseline (T1) at 1 week after intervention (T2))
- Vigorous physical activity(Change from baseline (T1) at 1 week after intervention (T2))
- Step count(Change from baseline (T1) at 1 week after intervention (T2))
- Blood pressure(Baseline (T1))