Comparison Of Effects Of Dexmedetomidine Vs Ivabradine On Mortality In Patients With Septic Shock A Randomized Controlled Trial

AIIMS JODHPUR1 个研究点分布在 1 个国家目标入组 210 人开始时间: 2026年1月30日最近更新: 2026年1月9日

试验速览

阶段: 不适用
状态: 尚未招募
发起方: AIIMS JODHPUR
入组人数: 210
试验地点: 1

研究概览研究设计入排标准研究者研究点记录与标识符相似试验

研究概览

简要总结

Sepsis, a life-threatening syndrome, is associated with autonomic dysregulation & elevated levels of catecholamines (noradrenaline/adrenaline), released from sympathetic nervous system. Although this adrenergic surge is initially adaptive, its persistence can exacerbate organ injury and eventual mortality.

Rudiger & Singer gave therapeutic approaches aimed at reducing excessive adrenergic stimulation. Drugs implicated - Dexmedetomidine, an alpha 2 agonist, and Ivabradine a funny current channel inhibitor. Both agents have been used in septic shock for reducing sympathetic surge. However no study has compared effect of both these agents on 28 day mortality.

研究设计

研究类型: Interventional
分配方式: Randomized
盲法: Participant and Investigator Blinded

入排标准

年龄范围: 18.00 Year(s) 至 99.00 Year(s)（—）
性别: All

入选标准

•Age more than 18 years Diagnosis of septic shock, as per Sepsis-3 definition Onset of septic shock within the past 24 hours Receiving norepinephrine as part of standard care Persistent sinus tachycardia (HR more than 100bpm) despite initial resuscitation Informed consent obtained from the patient or legally authorized representative.

排除标准

•Known hypersensitivity or contraindication to dexmedetomidine or ivabradine Presence of high-grade AV block, sick sinus syndrome, or severe bradycardia (HR less than 60 bpm) without a functioning pacemaker Acute coronary syndrome or decompensated heart failure within the past 7 days.
•Baseline left ventricular ejection fraction (LVEF) less than 30percent Severe hepatic impairment (Child-Pugh Class C).
•Severe renal impairment(CrCl less than 15ml/min) prior to enrolment Use of beta blockers, calcium channel blockers (verapamil/diltiazem), or other HR-lowering agents not safely discontinued Pregnancy or lactation Patients with do-not-resuscitate (DNR) status or expected death within 24 hours.

研究者

发起方

AIIMS JODHPUR

申办方类型

Research institution and hospital

责任方

Principal Investigator

主要研究者

Nikila Murugan

All India Institute Of Medical Sciences

研究点 (1)

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