NCT04062864已完成不适用
Validity of Pupil Diameter for Pain Monitoring During General Anesthesia in Children : a Prospective Observational Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- Pupil diameter
研究概览
简要总结
This study evaluates the validity of pupil diameter as an indicator of pain during surgery under general anesthesia.
详细描述
Pupil diameter is known to be strongly correlated with sympathetic tone. During surgery under general anesthesia, there is no standardized means of pain assessment. As pain activates sympathetic nervous system, we hypothesized that pupil diameter can be a marker for pain during surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 3 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children undergoing surgery under general anesthesia with total time of less than two hours
排除标准
- •Children whose parent or legal guardian declined to enroll
- •Any use of opioids during surgery
- •History of hypersensitivity to any anesthetic agents
- •Any medication that can affect sympathetic nervous activity
- •Presence of underlying ophthalmologic disease
结局指标
主要结局
Pupil diameter
时间窗: From start of anesthesia to end of anesthesia
Pupil diameter before and after painful stimuli (skin incision, train-of-four stimulation)
次要结局
- Bispectral index(From start of anesthesia to end of anesthesia)
- Pleth variability index(From start of anesthesia to end of anesthesia)
研究者
Hee-Soo Kim
Professor
Seoul National University Hospital
研究点 (1)
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