Iodine Nutrition Status and Clinical Characteristics of Thyroid Cancer

Recruiting

• Conditions: Thyroid Cancer
• Interventions: Dietary Supplement: Iodine excess; Dietary Supplement: Iodine suitable

• Registration Number: NCT06623500
• Lead Sponsor: Shandong Provincial Hospital

Brief Summary

The effect of iodine nutritional status on thyroid cancer has been controversial for many years. We designed a prospective cohort study that recruiting patients in different iodine areas who underwent thyroid cancer surgery in branch hospitals from 2012 to 2019，and follow up their clinical outcomes. We aimed to analyse the relationship between regional iodine nutrition level and pathological types, clinical features, and prognosis of thyroid cancer.

Detailed Description

Three sub centers were selected in high iodine (Jining/Liaocheng/Heze) and moderate iodine (Jinan/Shenyang/Haerbin) areas respectively. Patients lived in the above-mentioned regions for at least 5 years and diagnosed as thyroid cancer and underwent thyroid surgery in branch hospitals from 2012 to 2019 were recruited.

Study Timeline

• Study Start: 2012-01-01
• Status Verified: 2024-09
• Study First Submitted: 2024-09-25
• Study First Submitted QC: 2024-09-29
• Last Update Submitted: 2024-09-29
• Study First Posted: 2024-10-02
• Last Update Posted: 2024-10-02
• Primary Completion: 2026-12-01
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1600

Inclusion Criteria

1. Age range: 18~65 years old, gender not limited;
2. Living in the selected region for at least 5 years;
3. Patients who underwent thyroid surgery at various research centers were pathologically diagnosed with thyroid cancer;
4. The clinical data （general information、surgical scope 、pathological report、utrasonic report, etc ）of the case is complete.

Exclusion Criteria

1. Diagnosed as other types of cancer or thyroid metastatic cancer;
2. There are serious comorbidities such as heart, liver, and kidney diseases present;
3. Unable to follow up on prognostic information.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Excessive iodine group	Iodine excess	Residents with thyroid cancer who have lived in high iodine areas for a long time (5 years or more). According to the report of Shandong Institute of Endemic Disease Prevention and Control, three sub centers were selected in Excessive iodine group (Jining/Liaocheng/Heze).
Suitable iodine group	Iodine suitable	Residents with thyroid cancer who have lived in suitable iodine areas for a long time (5 years or more). According to the report of Shandong Institute of Endemic Disease Prevention and Control, three sub centers were selected in suitable iodine (Jinan/Shenyang/Haerbin) areas.

Primary Outcome Measures

Name	Time	Method
Number of participants with recurrence	from enrollment to the final follow-up at 5 years	Recurrence: diagnosed as the same type of thyroid cancer again by pathology
Number of participants with distant metastasis	from enrollment to the final follow-up at 5 years	Distant metastasis: Pathological confirmed thyroid cancer occurring outside the thyroid gland
All-cause mortality	from enrollment to the final follow-up at 5 years	The ratio of the total number of deaths caused by various reasons during the research period to the number of participants

Trial Locations

Locations (1)

Shandong Provincial Hospital; 🇨🇳 Jinan, Shandong, China