Prospective Cohort Study on Clinical Characteristics of Thyroid Cancer in Different Iodine Status Areas
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,600
- 试验地点
- 1
- 主要终点
- Number of participants with recurrence
研究概览
简要总结
The effect of iodine nutritional status on thyroid cancer has been controversial for many years. We designed a prospective cohort study that recruiting patients in different iodine areas who underwent thyroid cancer surgery in branch hospitals from 2012 to 2019，and follow up their clinical outcomes. We aimed to analyse the relationship between regional iodine nutrition level and pathological types, clinical features, and prognosis of thyroid cancer.
详细描述
Three sub centers were selected in high iodine (Jining/Liaocheng/Heze) and moderate iodine (Jinan/Shenyang/Haerbin) areas respectively. Patients lived in the above-mentioned regions for at least 5 years and diagnosed as thyroid cancer and underwent thyroid surgery in branch hospitals from 2012 to 2019 were recruited.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age range: 18~65 years old, gender not limited;
- •Living in the selected region for at least 5 years;
- •Patients who underwent thyroid surgery at various research centers were pathologically diagnosed with thyroid cancer;
- •The clinical data （general information、surgical scope 、pathological report、utrasonic report, etc ）of the case is complete.
排除标准
- •Diagnosed as other types of cancer or thyroid metastatic cancer;
- •There are serious comorbidities such as heart, liver, and kidney diseases present;
- •Unable to follow up on prognostic information.
结局指标
主要结局
Number of participants with recurrence
时间窗: from enrollment to the final follow-up at 5 years
Recurrence: diagnosed as the same type of thyroid cancer again by pathology
Number of participants with distant metastasis
时间窗: from enrollment to the final follow-up at 5 years
Distant metastasis: Pathological confirmed thyroid cancer occurring outside the thyroid gland
All-cause mortality
时间窗: from enrollment to the final follow-up at 5 years
The ratio of the total number of deaths caused by various reasons during the research period to the number of participants
次要结局
未报告次要终点
研究者
Hai-qing Zhang
Chief physician
Shandong Provincial Hospital