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Iodine Nutrition Status and Clinical Characteristics of Thyroid Cancer

Recruiting
Conditions
Thyroid Cancer
Registration Number
NCT06623500
Lead Sponsor
Shandong Provincial Hospital
Brief Summary

The effect of iodine nutritional status on thyroid cancer has been controversial for many years. We designed a prospective cohort study that recruiting patients in different iodine areas who underwent thyroid cancer surgery in branch hospitals from 2012 to 2019,and follow up their clinical outcomes. We aimed to analyse the relationship between regional iodine nutrition level and pathological types, clinical features, and prognosis of thyroid cancer.

Detailed Description

Three sub centers were selected in high iodine (Jining/Liaocheng/Heze) and moderate iodine (Jinan/Shenyang/Haerbin) areas respectively. Patients lived in the above-mentioned regions for at least 5 years and diagnosed as thyroid cancer and underwent thyroid surgery in branch hospitals from 2012 to 2019 were recruited.

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
1600
Inclusion Criteria
  1. Age range: 18~65 years old, gender not limited;
  2. Living in the selected region for at least 5 years;
  3. Patients who underwent thyroid surgery at various research centers were pathologically diagnosed with thyroid cancer;
  4. The clinical data (general information、surgical scope 、pathological report、utrasonic report, etc )of the case is complete.
Exclusion Criteria
  1. Diagnosed as other types of cancer or thyroid metastatic cancer;
  2. There are serious comorbidities such as heart, liver, and kidney diseases present;
  3. Unable to follow up on prognostic information.

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Number of participants with recurrencefrom enrollment to the final follow-up at 5 years

Recurrence: diagnosed as the same type of thyroid cancer again by pathology

Number of participants with distant metastasisfrom enrollment to the final follow-up at 5 years

Distant metastasis: Pathological confirmed thyroid cancer occurring outside the thyroid gland

All-cause mortalityfrom enrollment to the final follow-up at 5 years

The ratio of the total number of deaths caused by various reasons during the research period to the number of participants

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Shandong Provincial Hospital

🇨🇳

Jinan, Shandong, China

Shandong Provincial Hospital
🇨🇳Jinan, Shandong, China
Qingling Guo, doctor
Contact
13026575201
guoqinglingqhb@163.com
Haiqing Zhang, doctor
Contact
(86)15168888303
15168888303@163.com

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