Effects of Physical Training and Nutrition Education on Adipocytokines in Severely Obese Teenagers

Completed

• Conditions: Healthy; Obesity

• Registration Number: NCT01188642
• Lead Sponsor: Centre Hospitalier Universitaire de Besancon

Brief Summary

Obesity is now becoming significantly prevalent of an environment characterized by easily available calorics foods combined with sedentary lifestyles. Moreover, it has been demonstrated that obesity is associated with metabolic complications such as disturbed adipocytokines, hormones secreted by adipose tissue. Given these observations, the purpose of this study is to assess the effects of a lifestyle intervention focused on various physical activities and nutrition education on adipocytokines hormones, in severely obese teenagers.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-03
• Primary Completion: 2009-06
• Status Verified: 2010-08
• Study First Submitted: 2010-08-17
• Study First Submitted QC: 2010-08-24
• Last Update Submitted: 2010-08-24
• Study First Posted: 2010-08-25
• Last Update Posted: 2010-08-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

• to be aged from 12 to 17
• to have a body mass index > 97 percentile for age and gender

Exclusion criteria:

• systemic disease
• endocrine disorder
• syndromic obesity
• subjects receiving medication with a history of recent intercurrent illness

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Adipocytokines (leptin, adiponectin, ghrelin, PAI-1, resistin), based on subject's arterialized capillary blood samples.	during a lifestyle intervention of 9 months

Secondary Outcome Measures

Name	Time	Method
Glycemia and lipids profile, based on subject's arterialized capillary blood samples analysis.	during a lifestyle intervention of 9 months
Insulin resistance, calculated according to the formula of homeostasis model assessment	during a lifestyle intervention of 9 months
Body weight, body mass index, waist and hip circumference	during a lifestyle intervention of 9 months
Body composition, calculated by a multifrequency bioelectric impedance	during a lifestyle intervention of 9 months
Systolic and diastolic blood pressure, measured in millimeters of mercury at the level of the left brachial artery, using an automatic blood pressure monitor.	during a lifestyle intervention of 9 months

Trial Locations

Locations (1)

Centre Hospitalier Universitaire; 🇫🇷 Besançon, France