The efficacy of Double Ovarian Stimulation for enhancing oocyte yield in assisted reproductive technology in patients with poor ovarian response

Phase 2

• Conditions: POOR OVERIAN RESPONSE.; Ovarian dysfunction, unspecified; E28.9

• Registration Number: IRCT20200804048303N1
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 12 July 2021

Recruitment & Eligibility

• Status: Pending
• Sex: Female
• Target Recruitment: 34

Inclusion Criteria

Poor ovarian stimulation based on Poseidon group 3 criteria, AMH less than 1.2 ng / ml, antral follicle count less than 5 and age less than 35 years Group 4 poseidon includes older age equal to 35 years and AMH less than 1.2 ng/ml and the number of antral follicles less than 5 follicles
Group 4 poseidon includes older age equal to 35 years and AMH less than 1.2 ng/ml and the number of antral follicles less than 5 follicles

Exclusion Criteria

Women with normal or excessive ovarian response
Women with excessive ovarian response

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
umber of oocytes. Timepoint: Compare the number of oocytes and MII oocytes after induction ovulation in the follicular and luteal phase and two methods flare stimulation and minimal stimulation,. Method of measurement: Ultrasonography and puncture of oocytes and evaluate the presence of a polar body.;Number of embryos. Timepoint: Number of embryos after induction ovulation and oocyte retrieval in follicular and luteal phase and compare two methods of flare stimulation and minimal stimulation. Method of measurement: Inspection of embryos under the microscope.;Number of blastocysts. Timepoint: The number of blastocysts after oocyte retrieval in the follicular and luteal phases and compare the two methods of flare stimulation and minimal stimulation. Method of measurement: Inspection of embryos under the microscope 5days after oocyte retrieval.

Secondary Outcome Measures

Name	Time	Method
Clinical pregnancy. Timepoint: 4-6 weeks after embryo transfer(ET). Method of measurement: Transvaginal ultrasonography and observe existence of gestational sac and fetal heart rate.