EFFECT OF INSULIN SENSITIZER METFORMIN ON MARKERS OF ENDOTHELIAL DYSFUNCTION IN PSORIASIS PATIENTS WITH METABOLIC SYNDROME: A RANDOMISED CONTROL STUDY

Post graduate Institute of Medical Education and Research PGIMER Chandigarh0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•1. Patients with stable plaque psoriasis having mild to moderate disease severity not requiring systemic therapy i.e., PASI 1-10 and involvement of <10% of body surface area
•2. Metabolic syndrome i.e., the presence of three or more criteria of the Consensus definition for Asian Indians:
•(i)Waist circumference > 90 cm in men and > 80 cm in women
•(ii) Hypertriglyceridemia > 150 mg/dl
•(iii)High density lipoprotein (HDL) cholesterol Men < 40 mg/dl, Women <50 mg/dl.
•(iv)Blood pressure > 130/85 mm Hg
•(v)Fasting Blood glucose > 100 mg/dl
•3. Patients willing to provide written informed consent

•1. Psoriasis patients with severe disease (Involvement of >10% body surface area and PASI > 10)
•2. Patients with guttate, erythrodermic, or pustular psoriasis and psoriatic arthritis.
•3. Patients receiving systemic treatment.
•4. History, clinical findings on current examination indicative of cardiovascular disease.
•5. Renal insufficiency - serum creatinine >=1.5 mg/dL (men) or >=1.4mg/dL (women).
•6. Patients with significant hepatic impairment (serum bilirubin, AST, ALT and alkaline phosphatase >1.5 times the upper limit of normal).
•7. Pregnant or nursing women. Women of childbearing potential will be considered potentially eligible provided they are following barrier method of contraception.
•8. Any other chronic medical illness that may jeopardise interpretation of study results

发起方

Post graduate Institute of Medical Education and Research PGIMER Chandigarh