NL-OMON27248尚未招募不适用
A phase I/II post-cord blood HCT dendritic cell vaccination trial directed against WT1 for pediatric acute myeloid leukemia: the U-DANCE-anti-AML trial
niversity Medical Center Utrecht, The NetherlandsUMC Utrecht0 个研究点目标入组 54 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 54
研究概览
简要总结
de Haar C, Plantinga M, Blokland NJ, et al. Generation of a cord blood-derived Wilms Tumor 1 dendritic cell vaccine for AML patients treated with allogeneic cord blood transplantation. oncoimmunology. 2015;4(11):e1023973–12.
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Pediatric AML patients eligible for allo-HCT according to standard-of-care guidelines, with overexpression of WT1 mRNA in an AML sample (>50 copies WT1/10^4 copies ABL for PB and >250 copies WT1/10^4 copies ABL for BM 52 taken at diagnosis and/or relapse after (re-)induction chemotherapy.
- •Indication for CB-HCT according to the UMC Utrecht guidelines
排除标准
- •Patients undergoing allo-HCT with stem cells derived from PBMCs or BM
- •Patients who are pregnant or breast-feeding or unwilling to use adequate contraceptive methods
研究者
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