De zoete inval: zijn versuikerde eiwitten in voeding betrokken bij het ontstaan van type 2 diabetes?

Completed

Conditions: Advanced glycation end-products, insulin sensitivity, vascular function, insulin resistance, microbiotaVersuikerde eiwitten, insuline gevoeligheid, insuline resistentie, vaatfunctie, microbioom

Registration Number: NL-OMON20660

Lead Sponsor: Maastricht University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 82

Inclusion Criteria

•Caucasian

•Abdominal obesity: waist circumference men ≥ 102 cm, and women ≥ 88 cm.

Exclusion Criteria

•Diabetes (i.e. using anti-diabetic medication, fasting glucose >7.0 mmol/L, HbAc1 > 6.5%).

•Active or history of cardiovascular disease (e.g. stroke, coronary artery disease, peripheral vascular disease, congestive heart failure, cardiac shunts, cardiac surgery, pulmonary hypertension, cardiac arrhythmias, family history of cardiac arrhythmias, or sudden cardiac death).

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary objective of this study is to investigate the effect of dietary AGE restriction on whole-body insulin sensitivity measured by the hyperinsulinaemic-euglycaemic clamp.

Secondary Outcome Measures

Name	Time	Method
•Micro- and macrovascular function by means of funduscopy, endothelial glycocalyx thickness, skin capillary videomicroscopy, skin laser Doppler flowmetry, contrast-enhanced ultrasound (CEUS), flow mediated vasodilation (FMD), pulse wave velocity and analysis, and carotid distensibility.<br /><br>•AGE measurements in blood plasma, urine and skin. The latter by means of skin autofluorescence (SAF).<br /><br>•Glucose metabolism and β-cell function during two consecutive 30-min hyperglycaemic steps.<br /><br>•Markers of endothelial function, inflammation, and adipokine markers in blood plasma.<br /><br>•Composition of the gut microbiota using 16S rRNA sequencing.<br>