Exercise and Weight Control: A Search for Biological and Neurobehavioral Compensatory Mechanisms That Defend Against Exercise-Induced Negative Energy Balance
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Accumulated Energy Balance
研究概览
简要总结
The objective of this project is to determine the biological, neurobehavioral, and behavioral compensatory responses to exercise training-induced energy deficits in overweight to obese men and women. Participants will engage in exercise at either 2 days or 6 days per week for 12 weeks and have body composition assessed via DXA before and after the exercise intervention. Accumulated energy balance (weight loss converted to kcal) will be compared to exercise energy expenditure to determine each individual's level of compensation, termed compensation index. Predictors of compensation index that will be assessed will include hunger/satiety hormone concentrations at rest and in response to a meal, reward driven feeding, changes in metabolic rate, and energy intake throughout the intervention. Exercise reinforcement and physical activity will also be assessed as a separate aim to determine if exercise reinforcement can be increased and if this can promote greater habitual physical activity after the intervention has ceased.
详细描述
Study Design: A factorial design will be employed with exercise frequency (6 days/week or 2 days/week) treated as a between-subjects variable and time (baseline, end of training, end follow-up) treated as a within subjects variable. Subjects will be randomly assigned to exercise groups (6 days/week, 2 days/week) or sedentary control. The control group will be offered the intervention (personalized exercise plan, provided membership to YMCA) after follow-up measures.
Study Population:
This study will aim to complete all assessments on 60 participants
Inclusion Criteria:
- Male or female between the ages of 18 and 40
- Participants must be overweight to obese (BMI 25-35 kg/m2) Not pregnant or lactating or planning to become pregnant in the next 6 months
- No limitations to safely participating in physical activity
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants must be overweight to obese (BMI 25-35 kg/m2) Not pregnant or lactating or planning to become pregnant in the next 6 months
- •No limitations to safely participating in physical activity
排除标准
- •Currently dieting to lose weight and no weight loss or gain >2kg over the past 3 months,
- •Taking any medications that affect energy expenditure or eating,
- •Regularly exercising (planned and structured aerobic or resistance activity).
- •Participants must have no major health problems, cannot have known cardiovascular (cardiac, peripheral vascular, cerebrovascular), pulmonary (COPD, interstitial lung disease, cystic fibrosis) or metabolic (diabetes, thyroid disorders, renal or liver disease) disease.
- •Tobacco use
- •Have a medical condition that prevents safe exercise.
结局指标
主要结局
Accumulated Energy Balance
时间窗: determined at 12 weeks by comparing to baseline data
Change in energy balance assessed via DXA (weight loss)
次要结局
- Habitual physical activity(baseline to 12 weeks, 12 weeks to 16 weeks, baseline to 16 weeks)
- Resting metabolic rate(baseline to 12 weeks)
- Compensation index(determined at 12 weeks by comparing to baseline data)
- Hormonal responses to meal and fasting levles(baseline to 12 weeks)
- Changes in dietary intake(baseline to 12 weeks)
- Food reinforcment(baseline to 12 weeks)
- Exercise reinforcement(baseline to 12 weeks, 12 weeks to 16 weeks, baseline to 16 weeks.)
研究者
Kyle Flack
Principle Investigator
University of Kentucky