Investigating cardiometabolic risk factors and changes in chronobiology patterns in patients with autonomous adrenal cortisol secretion

Medical University of Vienna, Division of Endocrinology0 个研究点目标入组 50 人开始时间: 2022年6月8日最近更新: 2022年8月8日

试验速览

暂无简介。

•For patients with autonomous cortisol secretion:
•i) morning cortisol > 5 ug/dl following 1 mg dexamethasone suppression test or ii) cortisol 1,8-5 ug/dl following 1 mg dexamethasone suppression test with a low morning ACTH concentration (ACTH < 10 pg/ml), without classical clinical features associated with the presence of Cushing’s syndrome.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 40
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 10

•HbA1c > 7 % and/or treatment with other anti-diabetics than metformin and/or DPP-IV inhibitors
•uncontrolled hypertension (RR > 170/110 mmHg; treatment with no more than 3 antihypertensive drugs)
•previous treatment with glucocorticoids within the last 3 months
•concomitant treatment with drugs affecting HPA signaling or CYP3A4 metabolism
•adrenal tumor with radiological criteria suspicious for malignancy
•chronic kidney disease (eGFR < 45 ml/min)
•liver disease (ASAT / ALAT > 3 x ULN)
•pregnancy or breast feeding
•general MR contraindications (claustrophobia, metal devices or other magnetic material in the body which will be hazardous for MR investigation

发起方

Medical University of Vienna, Division of Endocrinology