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A Phase II Study to Evaluate the Effects of Oral ONO-5129 in Type 2 Diabetes Mellitus

Phase 2
Completed
Conditions
Diabetes Mellitus, Type 2
Registration Number
NCT00212641
Lead Sponsor
Ono Pharma USA Inc
Brief Summary

The objectives of this study are to characterize the pharmacodynamic profile, safety and tolerability of ONO-5129 in patients with Type 2 Diabetes mellitus

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
105
Inclusion Criteria
  1. Type 2 Diabetes Mellitus
  2. FBG level > 140 mg/dL and < 270 mg/dL
  3. Fasting TG level < 500 mg/dL
  4. BMI of 22 to 40 kg/m2, inclusive
  5. Other Inclusion criteria as specified in the study protocol
Exclusion Criteria
  1. Previous participation in an ONO-5129 protocol
  2. Previous treatment with TZD agents or other current antidiabetics
  3. History of myocardial infarction, coronary artery surgery, atrial/ventricular tachycardia, or atrial/ventricular fibrillation in the past six months
  4. Presence of functional limitations due to cardiovascular disease in accordance with the New York Heart Association Classification System - Class III (moderate) or IV (severe)
  5. Other exclusion criteria as specified in the study protocol

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
Fasting Blood Glucose at 8 weeks
Secondary Outcome Measures
NameTimeMethod
Pharmacodynamic parameters at all time points

Trial Locations

Locations (67)

Renaissance Clinical Research

🇺🇸

Dallas, Texas, United States

Founders Medical Practice

🇺🇸

Philadelphia, Pennsylvania, United States

Executive Health and Research Associates, Inc.

🇺🇸

Atlanta, Georgia, United States

Acadia Clinical Research, LLC

🇺🇸

Bangor, Maine, United States

Franklin Square Hospital Center

🇺🇸

Baltimore, Maryland, United States

Cllinical Research Consultants

🇺🇸

Medford, Oregon, United States

Capital City Family Medicine

🇺🇸

Boise, Idaho, United States

Quality Care Medical Center

🇺🇸

Vista, California, United States

Orthopedic Health Care Clinic

🇺🇸

Boise, Idaho, United States

Encompass Clinical Research

🇺🇸

Spring Valley, California, United States

Sonora Clinical Research

🇺🇸

Boise, Idaho, United States

Clinic of Physicians and Surgeons

🇺🇸

Mesa, Arizona, United States

Alliance Medical Reserach Group, Inc.

🇺🇸

Clearwater, Florida, United States

Century Clinical Research, Inc

🇺🇸

Holly Hill, Florida, United States

Innovative Research of West Florida

🇺🇸

Largo, Florida, United States

Wells Institute for Health Awareness

🇺🇸

Kettering, Ohio, United States

Fallen Timbers Internal Medicine LLC

🇺🇸

Maumee, Ohio, United States

Family Medical Center

🇺🇸

Foothill Ranch, California, United States

Prime-Care Clinical Research

🇺🇸

Mission Viejo, California, United States

Institute Diabetes and Metabolic Disease

🇺🇸

Newark, Delaware, United States

Arapahoe Internal Medicine

🇺🇸

Littleton, Colorado, United States

Winthrop University Hospital

🇺🇸

Mineola, New York, United States

Horizon Clinical Research Associates

🇺🇸

Mesa, Arizona, United States

Sagebrush Medical Plaza, Department of Family Medicine

🇺🇸

Bakersfield, California, United States

Professional for Clinical Research

🇺🇸

Plano, Texas, United States

Orange County Research Center

🇺🇸

Tustin, California, United States

Dolby Research, LLC

🇺🇸

Baton Rouge, Louisiana, United States

Cochise Clinical Research

🇺🇸

Sierra Vista, Arizona, United States

Professional Clinical Reserach -Great Lakes Family Care

🇺🇸

Cadillac, Michigan, United States

John Joseph, MD PA

🇺🇸

Carrollton, Texas, United States

Medex Healthcare Research, Inc

🇺🇸

Saint Louis, Missouri, United States

Mercury Street Medical

🇺🇸

Butte, Montana, United States

United Physicians Group - Endocrine Division

🇺🇸

Great Neck, New York, United States

Spartanburg Medical Research

🇺🇸

Spartanburg, South Carolina, United States

Liberty Research Center

🇺🇸

Tacoma, Washington, United States

Hyperion Clinical Trials, Inc.

🇺🇸

Charleston, West Virginia, United States

Specialty Medical Center

🇺🇸

Pahrump, Nevada, United States

Research Across America

🇺🇸

Plano, Texas, United States

Thomas Jefferson University Div of Endocrinology

🇺🇸

Philadelphia, Pennsylvania, United States

Greenand Seidner Family Practice

🇺🇸

Lansdale, Pennsylvania, United States

Cedar-Crosse Research Center

🇺🇸

Chicago, Illinois, United States

Chicago Research Center, Inc.

🇺🇸

Chicago, Illinois, United States

MCA Research

🇺🇸

Houston, Texas, United States

Southwest Houston Research, LTD

🇺🇸

Houston, Texas, United States

New Horizons Clinical Research

🇺🇸

Cincinnati, Ohio, United States

Apex Clinical Trials, Inc.

🇺🇸

Birmingham, Alabama, United States

Greystone Medical Research, LLC

🇺🇸

Birmingham, Alabama, United States

COR Clinical Reserch, LLC

🇺🇸

Oklahoma City, Oklahoma, United States

Covance Clinical Research Unit, Inc

🇺🇸

Portland, Oregon, United States

Michael A. Azorr, M.D.

🇺🇸

Portland, Oregon, United States

Research Endeavors

🇺🇸

Pittsburg, Pennsylvania, United States

Benjamin Garwood Research

🇺🇸

San Antonio, Texas, United States

WellMed at Northern Hills

🇺🇸

San Antonio, Texas, United States

Diabetes and Glandular Disease Research Associates

🇺🇸

San Antonio, Texas, United States

Diabetes and Glandular Disease - Westside office

🇺🇸

San Antonio, Texas, United States

Medical Affiliated Research Center

🇺🇸

Huntsville, Alabama, United States

Med Search, LLC

🇺🇸

Calera, Alabama, United States

Personal Physician Care

🇺🇸

Delray Beach, Florida, United States

Cardiovascular Center of Sarasota

🇺🇸

Sarasota, Florida, United States

Heart of America Research

🇺🇸

Shawnee, Kansas, United States

DiGiovanna Family Care Center

🇺🇸

Great Neck, New York, United States

Centennial Medical Group

🇺🇸

Elkridge, Maryland, United States

Synergy Medical Education Alliance

🇺🇸

Saginaw, Michigan, United States

Bassett Healthcare

🇺🇸

Cooperstown, New York, United States

Southeastern PA Medical Institute

🇺🇸

Havertown, Pennsylvania, United States

Keystone Clinical Solutions

🇺🇸

Altoona, Pennsylvania, United States

Hillcrest Clinical Research LLC

🇺🇸

Simpsonville, South Carolina, United States

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