Pediatric Neuromyelitis Optica Spectrum Disorder (NMOSD) 1 Year Observational Study

This study is being done to collect information on the natural history of NMOSD in pediatric AQP4-IgG seropositive patients. A major restriction in performing drug studies in pediatric patients with NMOSD is limited information on the course of the disease in these patients. Collecting clinical information over the course of a 1 year observational study would inform on the natural history of the disease in these patients. A repository of pediatric patients with rare diseases can increase knowledge on the natural history of the specific disease, assist in identifying appropriate patients fulfilling specified criteria for drug studies and potentially serve as a control group.

Timepoints: Baseline, 3mo, 6mo, 9mo, 12mo (+/- 1 mo for each time point).

Baseline data:

• Demographics [age/sex/ethnicity],
• Clinical presentation information including date of initial diagnosis,
• Clinical phenotype
• Immunotherapy used current and past,
• Family history of autoimmune diseases,
• Serological data results
• Radiologic data as available

Self-Report Assessments will be: