Comparison of analgesic effect of Acetaminophen and Acetaminophen Codeine with caffeine in control of control preapical periodontitis pai
Phase 2
- Conditions
- Acute apical periodontitis pain.Acute apical periodontitis of pulpal origin
- Registration Number
- IRCT201304121760N22
- Lead Sponsor
- Vice Chancellor for Research and Technology, Babol University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Having severe pain scale of 7; Patient's ability to read, write and understand the concept of Visual Analog Scale; Non-housing consumption of 4 hours before the study, aged between 16 and 65 years.
Exclusion criteria:
A systemic disease.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Acute apical periodontitis pain. Timepoint: Every 10 minutes up to 120 minutes after drug. Method of measurement: Scale Visual Analog Scale (VAS).
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie caffeine's adjuvant effect in acetaminophen-codeine analgesia for acute apical periodontitis?
How does acetaminophen-codeine with caffeine compare to ibuprofen in managing pulpal-origin acute apical periodontitis pain?
Which inflammatory biomarkers (e.g., CRP, IL-6) correlate with analgesic response in IRCT201304121760N22 trial participants?
What are the safety profiles of acetaminophen-codeine-caffeine combinations versus monotherapies in phase II dental pain trials?
How do adenosine receptor antagonists like caffeine enhance opioid-sparing effects in acute apical periodontitis treatment strategies?