Investigating methods of reducing cancer recurrence by changing tissue drainage systems at the time of operation.

Not Applicable

• Conditions: Cervical cancer; Prostate cancer; Cancer - Cervical (cervix); Anaesthesiology - Anaesthetics; Cancer - Prostate

• Registration Number: ACTRN12612001162808
• Lead Sponsor: Peter MacCallum Cancer Centre

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-11-01
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

Patients presenting for brachytherapy for cervical or prostatic carcinoma at Peter MacCallum Cancer Centre;
- Patients requiring Magnetic Resonance Imaging after first treatment (and hence requiring a spinal anaesthetic).

Exclusion Criteria

- Abnormal pre-existing lymph flow or sympathetic tone including: Complex Regional Pain Syndrome (CRPS), lymphoedema of any cause, surgery or trauma to the lower extremities and any cutaneous or sub cutaneous inflammation in the lower extremities;
- Obesity as defined BMI >30kg/m2;
- Diabetes Mellitus (type 1 and 2);
- Patients currently on beta blockers or alpha antagonists;
- Clinically or otherwise (Ultrasound) demonstrated lymphadenopathy;
- Absent motor block prior to performing second lymphoscintigram;
- Acute use of Non-Steroidal Anti-Inflammatory Drugs (last 24hours) preceding lymphoscintigram.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ratio of groin sentinel node tracer activity to injection site activity as assessed by lymphoscintigraphy under control and exposure conditions.[At 60 and 120 minutes after injection of colloid tracer.]

Secondary Outcome Measures

Name	Time	Method
il[Nil]