Effect of percutaneous transluminal angioplasty on endothelial function in patients with peripheral arterial disease
Not Applicable
- Conditions
- Peripheral arterial disease
- Registration Number
- JPRN-UMIN000008762
- Lead Sponsor
- Department of Cardiovascular Medicine, Juntendo University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Not provided
Exclusion Criteria
1) Patients who receive hemodialysis. 2) Patients who had received amputation of any lims. 3) Patients who are scheduled for a percutaneous transluminal angioplasty for the lesion below knee. 4) Patients who are scheduled for a percutaneous coronary intervention within a month. 5) Patients who had experienced acute coronary syndrome within 6 months. 6) Patients who have systemic inflammatory diseases including collagen diseases and infections. 7) Patients judged to be unsuitable participants by physician-in-charge.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1) Change of endothelial function by Endo-PAT 2) Change of circulating levels of myolines (Follistatin-like 1, IL-6, IL-7, IGF-1, FGF-2) 3) change of peripheral blood mononuclear cellprofileand numbers of endothelial progenitor cells and hematopoietic cells.
- Secondary Outcome Measures
Name Time Method 1) Fontaine classification 2) Ankle brachial index 3) Skin perfusion pressure 4) Body weight, body mass index, blood pressure, muscle mass of lower legs 5) hs CRP levels 6) Renal function and liver fuction tests