A Retrospective and Prospective, Observational, Real World Multi-cohort Study of Patients With Non-small Cell Lung Cancer (NSCLC) Initiating Approved Drugs Developed by AZ or as Part of an AZ Alliance

Registration Number
NCT06726720
Lead Sponsor
AstraZeneca
Brief Summary

This is an ambispective, observational, multicenter and multicohort study, targeting patients with NSCLC initiating approved drugs developed by AZ or as part of an AZ alliance, in the participating countries, as monotherapy or in combination at any stage of disease. Three cohorts are designed, based on the stage of NSCLC (resectable, unresectable and metasta...

Detailed Description

Not available

Recruitment & Eligibility

Status
NOT_YET_RECRUITING
Sex
All
Target Recruitment
300
Inclusion Criteria
  • Adult patients (≥ 18 years old)
  • Patients with histologically or cytologically proven NSCLC
  • Patients initiated with approved drugs developed by AZ or as part of an AZ alliance at the time of the enrollment or within the previous three weeks.
  • Informed patients who consent to participate in the study as per local regulations.
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Exclusion Criteria
  • Patients participating in an interventional clinical trial for NSCLC*

    * with the exception on low-interventional studies (RIPH2) where the intervention does not involve the NSCLC treatment

  • Patients already enrolled in another module of the cohort in UMBREALUNG

  • Patients under safeguard of justice, curatorship or guardianship

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Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Cohort A (resectable NSCLC) rw DFS3 to 5 years

real-world Disease-Free Survival (rwDFS) for adjuvant protocol assessment

Cohort B (unresectable NSCLC): rwTFST1 to 3 years

real-world time to first subsequent systemic therapy (rwTFST)

Cohort C (metastatic NSCLC) rw TFST1 to 3 years

real-world time to first subsequent systemic therapy (rwTFST)

Secondary Outcome Measures
NameTimeMethod
Additional criteria of effectiveness8 years
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