Assessment of efficacy of dexamethasone as compared to prednisolone as first line oral steroid for remission of thrombocytopenia in acute immune thrombocytopenic purpura in children, a single centered open label randomized control trial.

The study has been proposed to be done by the Department of Paediatric Medicine.Purpose of the study is to determine the efficacy of dexamethasone when compared to prednisolone as a first line steroid to be used in patients of acute ITP in children. Once the diagnosis of ITP has been established a baseline CBC will be done to look for platelet counts and other haematological parameters. Children will then be allotted a group by randomisation using an opaque sealed enveloped technique and will be divided in group A (will receive Dexamethasone 40 mg for a total duration of 4 days) and group B (will receive Prednisolone at 2 mg/kg/day for 14 days and then taper over next 2 weeks). Child will be monitored for bleeding manifestations. A repeat CBC will be done as per clinical indication and at 1 and 3 months following the initial presentation. Then the child will be evaluated for complete response, response and no response. Then using relevant statistical test, the outcome will be inferred.The interested subjects who are willing to participate in the research will be given the Participant Informed consent form (PICF) which they are abide to fill after reading. Further, the data will be captured in a Data capture sheet. The data will be collected, assembled and analysed using Statistical Product and Service Solutions (SPSS version 22) software package for Windows/Mac, Student Edition.