Skin Surface and Intradermal Temperature Responses to Heat Stress
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hyperthermia
- Sponsor
- University of Texas Southwestern Medical Center
- Enrollment
- 9
- Locations
- 1
- Primary Endpoint
- Skin Temperature with Fan Only
- Status
- Active, not recruiting
- Last Updated
- 9 months ago
Overview
Brief Summary
The purpose of this study is to compare surface and intradermal skin temperature responses to heat stress with and without evaporative and convective cooling.
Detailed Description
Humans have important thermoregulatory responses aimed at maintaining body temperature within a narrow range. These responses are driven in part by receptors located in the skin that monitor temperature changes and provide feedback to the central nervous system. Given that skin temperature can affect the physiological responses to heat stress, it is important to accurately measure skin temperature in response to heat stress with and without evaporative (i.e., sweat) and convective (i.e., air flow) cooling. Skin temperature is most often measured on the surface of the skin; however, this temperature can be influenced by other factors such as the local environment. It is unclear how the temperature of the skins surface compares to the temperature within the dermal layer of the skin. The study team will directly compare skin surface and intradermal temperature responses to heat stress and determine whether these responses area altered by evaporative or convective cooling methods. To accomplish this objective, healthy adults will be exposed to ambient heat stress (no higher than 47°C) with and without evaporative (water sprayed on the skin) and convective (electric fan) cooling. Thermoregulatory responses, inclusive of skin surface and intradermal temperatures, will be assessed throughout the heat trial.
Investigators
Craig Crandall
Professor of Internal Medicine
University of Texas Southwestern Medical Center
Eligibility Criteria
Inclusion Criteria
- •Free of any significant underlying medical problems based upon a detailed medical history and physical exam.
- •Normal resting electrocardiogram.
Exclusion Criteria
- •Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, etc.; as well as serious abnormalities detected on routine screening.
- •Individuals who are pregnant, planning to become pregnant, or breastfeeding.
- •Taking prescribed medications (such as beta blockers and non-dihydropyridine calcium channel blockers) or over-the-counter medications that have known influences on thermoregulatory response.
- •Current smokers, as well as individuals who regularly smoked within the past 3 years.
Outcomes
Primary Outcomes
Skin Temperature with Fan Only
Time Frame: 40 minutes into the heat intervention.
Skin temperature will be measured from small temperature sensitive electrodes attached to the surface and intradermal layer of the skin of the participant with the fan cooling modality.
Skin Temperature with Fan and Water Spray
Time Frame: 60 minutes into the heat intervention.
Skin temperature will be measured from small temperature sensitive electrodes attached to the surface and intradermal layer of the skin of the participant with both the fan and water spray cooling modalities.
Skin Temperature with Water Spray Only
Time Frame: 1 hour 20 minutes into the the heat intervention.
Skin temperature will be measured from small temperature sensitive electrodes attached to the surface and intradermal layer of the skin of the participant with the water spray cooling modality.
Skin Temperature with No Cooling
Time Frame: 20 minutes into the heat intervention.
Skin temperature will be measured from small temperature sensitive electrodes attached to the surface and intradermal layer of the skin of the participant during the heat intervention with no cooling.