Velcade®-Melphalan Association as Conditioning Regimen Before Autologous Stem-cell Transplantation in Multiple Myeloma Patients Under 65 Years
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 61
- 试验地点
- 34
- 主要终点
- Evaluate the Complete Response and Very Good Partial Response (VGPR) rates 3 months after autologous blood stem cell transplantation conditioned by Velcade-Melphalan
研究概览
简要总结
Intensification with autologous stem cell (ASCT) is currently the most effective treatment for subjects under 65 and the essential goal is to achieve complete response (CR) or very good partial response (VGPR= greater than 90% reduction of monoclonal component). However, only 50% of patients achieve this CR/VGPR even with tandem ASCT early in the course of disease.
Optimization of the conditioning regimen could improve this CR/VGPR rate. The combinaison of Velcade and HD Melphalan has never been evaluated. However, at conventional doses, Velcade potentiates the antimyeloma effect of Melphalan without inducing any common toxicity.
This study will be conducted in patients under the age of 65 with de novo multiple myeloma or in first relapse, with Salmon and Durie stage of III, II, I with one symptomatic bone lesion (radiological)and no contraindication to intensification. The primary objective will be to increase the CR/VGPR rate 3 months after autologous peripheral blood stem cell transplantation conditioned by Velcade-Melphalan from 40% to 70%. With alpha=5% and bêta=10%, 61 patients will be included.
Secondary objectives will be to assess the toxicity of the Velcade-Melphalan conditioning regimen, the progression-free survival and the overall survival after intensification. Response rates will be evaluated according to the response criteria defined by. Analysis will be performed on an intention-to-treat basis.
After conventional induction therapy and PBSC collection, patients will be offered this new conditioning regimen. they will be free to refuse this regimen, in which case they will receive standard intensification therapy by Melphalan 200 mg/m² followed by autologous stem cell transplantation.
Evaluation will occur at 3 months post intensification.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •At time of diagnosis
- •De novo multiple myeloma patients under 65 or in first relapse, in whom screening for chromosome 13 deletion and beta2microglobulin assay have been performed.
- •Salmon and Durie Stage: III, II, I with symptomatic bone lesion (radiological)
- •Patient's written informed consent
- •No clinical signs of heart failure or coronary insufficiency with LVEF>50%
- •No hepatic in insufficiency: bilirubin<35μmol/l and SGOT, SGPT, alkaline phosphatase less than 2.5 N
- •No respiratory insufficiency: normal pulmonary function tests and DLCO>50%
- •No pre-existing renal impairment not related to the disease
- •No history of any other malignant disease with the exception of basal cell carcinoma and stage I cervical cancer
- •Negative HIV serology
- •Effective contraception when justified
- •At the time of transplantation
- •Good performance status (WHO score≤2)
- •Creatinine≤170μmol/l and no ineligibility criteria for intensification
- •Stem cells harvest ≥ 5x10E6 CD34/kg for 2 ASCT
- •Absence of progressive disease before transplantation
排除标准
- •Known refusal of the subject to participate to the study
- •Female subject who is pregnant or breast-feeding
- •History of allergy to any of the study medications, their analogues, or excipients in the various formulations
- •Main liver insufficiency
- •≥ Grade 3 peripheral neuropathy on clinical examination within 14 days before enrollment
研究组 & 干预措施
1
bortézomib
干预措施: Bortezomib (Drug)
结局指标
主要结局
Evaluate the Complete Response and Very Good Partial Response (VGPR) rates 3 months after autologous blood stem cell transplantation conditioned by Velcade-Melphalan
时间窗: 3 months after autologous stem cell transplantation
次要结局
- Assess the toxicity of this Velcade-Melphalan conditioning regimen (hematological and visceral toxicity-NCI criteria) - To assess the progression-free survival after transplantation - To assess the overall survival after tran(3 months)