PROGENI (Parkinson's Research: The Organized Genetics Initiative) Family Study of LRRK2 (Leucine-rich Repeat Kinase 2)

Completed

• Conditions: Parkinson Disease

• Registration Number: NCT01536821
• Lead Sponsor: Indiana University

Brief Summary

The PROGENI Family Study is part of a larger consortium that is studying a gene shown to be important in Parkinson's disease, called LRRK2. People who have a defect in the LRRK2 gene will often develop Parkinson's disease. Eligible participants will be asked to complete a single Study Visit at an affiliated research facility closest to their home.

Detailed Description

Participants will be asked to complete a family history questionnaire, which will gather information about their family history of Parkinson's disease and related disorders. They will be asked to complete a single Study Visit, during which they will be asked to do some or all of the following:

1. Complete questionnaires regarding Parkinson's disease symptoms, medical history, mood, sleep, mental status, and activity level.

2. Be given a brief standard neurological examination.

3. Be given a scratch and sniff smell identification test.

4. Be asked to give a sample of approximately 2 tablespoons of blood.

5. Be asked to give a urine sample of approximately 1 tablespoon of urine.

Study Timeline

• Study Start: 2011-05
• Study First Submitted: 2012-02-16
• Study First Submitted QC: 2012-02-21
• Study First Posted: 2012-02-22
• Status Verified: 2013-04
• Primary Completion: 2013-12
• Study Completion: 2013-12
• Last Update Submitted: 2013-12-13
• Last Update Posted: 2013-12-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 81

Inclusion Criteria

Positive for a LRRK2 mutation

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Observation and biological specimen collection	1 time

Trial Locations

Locations (10)

Cleveland Clinic Florida; 🇺🇸 Weston, Florida, United States

Indiana University Medical Center; 🇺🇸 Indianapolis, Indiana, United States

Kansas University Medical Center; 🇺🇸 Kansas City, Kansas, United States

University of Alberta; 🇨🇦 Edmonton, Alberta, Canada

University of Maryland School of Medicine; 🇺🇸 Baltimore, Maryland, United States

Oregon Health & Science University; 🇺🇸 Portland, Oregon, United States

Beth Israel Medical Center; 🇺🇸 New York, New York, United States

University of Iowa Hospitals; 🇺🇸 Iowa City, Iowa, United States

University of Nebraska; 🇺🇸 Omaha, Nebraska, United States

Medical University of Ohio; 🇺🇸 Toledo, Ohio, United States