PROGENI (Parkinson's Research: The Organized Genetics Initiative) Family Study of LRRK2 (Leucine-rich Repeat Kinase 2)
- Conditions
- Parkinson Disease
- Registration Number
- NCT01536821
- Lead Sponsor
- Indiana University
- Brief Summary
The PROGENI Family Study is part of a larger consortium that is studying a gene shown to be important in Parkinson's disease, called LRRK2. People who have a defect in the LRRK2 gene will often develop Parkinson's disease. Eligible participants will be asked to complete a single Study Visit at an affiliated research facility closest to their home.
- Detailed Description
Participants will be asked to complete a family history questionnaire, which will gather information about their family history of Parkinson's disease and related disorders. They will be asked to complete a single Study Visit, during which they will be asked to do some or all of the following:
1. Complete questionnaires regarding Parkinson's disease symptoms, medical history, mood, sleep, mental status, and activity level.
2. Be given a brief standard neurological examination.
3. Be given a scratch and sniff smell identification test.
4. Be asked to give a sample of approximately 2 tablespoons of blood.
5. Be asked to give a urine sample of approximately 1 tablespoon of urine.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 81
Positive for a LRRK2 mutation
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Observation and biological specimen collection 1 time
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (10)
Cleveland Clinic Florida
🇺🇸Weston, Florida, United States
Indiana University Medical Center
🇺🇸Indianapolis, Indiana, United States
University of Iowa Hospitals
🇺🇸Iowa City, Iowa, United States
Kansas University Medical Center
🇺🇸Kansas City, Kansas, United States
University of Maryland School of Medicine
🇺🇸Baltimore, Maryland, United States
University of Nebraska
🇺🇸Omaha, Nebraska, United States
Beth Israel Medical Center
🇺🇸New York, New York, United States
Medical University of Ohio
🇺🇸Toledo, Ohio, United States
Oregon Health & Science University
🇺🇸Portland, Oregon, United States
University of Alberta
🇨🇦Edmonton, Alberta, Canada
Cleveland Clinic Florida🇺🇸Weston, Florida, United States