Intracardiac Hemodynamics and Myocardial Strain in Athletes and First Responders

Completed

• Conditions: Cardiac Structure and Function; Intracardiac Hemodynamic
• Interventions: Behavioral: exercise

• Registration Number: NCT06075342
• Lead Sponsor: Chengdu Sport University

Brief Summary

The goal of this observational study is to compare the differences of intracardiac hemodynamics and myocardial strain in athletes with different training levels to adapt to long-term high-level training in rest conditions. The main questions aim to answer are: 1. whether an increase in amplitude and duration of intracardiac hemodynamics and myocardial strain compared with healthy controls; 2. Whether significant correlations exist between the hemodynamic indices and training level.

Participants will be asked to filling out the questionnaire, such as the age, training year (the number of years the athlete has participated in any sport), technical hierarchy (promoted by the Competitive Sports Department of the General Administration of Sport of China, weekly training time in the last 6 months, height, weight, body surface area, heart rate, systolic blood pressure, and diastolic blood pressure; and will be asked to perform an examination of transthoracic echocardiography.

Researchers will compare differences of cardiac structure and function, especially the hemodynamics and myocardial strain to see if training level could affect the cardiac function through hemodynamics and myocardial strain.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-03-01
• Primary Completion: 2023-07-30
• Study First Submitted: 2023-09-26
• Study First Submitted QC: 2023-10-03
• Study First Posted: 2023-10-10
• Status Verified: 2024-07
• Last Update Submitted: 2024-07-29
• Study Completion: 2024-07-30
• Last Update Posted: 2024-07-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• athletes and healthy control subjects without regular exercise habits;
• no specific medical history or chronic illness.

Exclusion Criteria

• A previous history of arterial hypertension, diabetes mellitus, heart, kidney, hepatic, infectious, psychiatric, malignant, disorders, taking drugs that can influence ECG intervals, and electrolyte imbalance;
• poor echocardiographic image quality and abnormal segmental ventricular wall movement.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
elite athlete	exercise	training year \> 10 years and weekly training time \> 20 hours
healthy control	exercise	healthy participants with irregular exercise habits
casual player	exercise	training year \< 10 years and weekly training time \< 20 hours
first responder	exercise	first responders with regular exercise training

Primary Outcome Measures

Name	Time	Method
intracardiac hemodynamics in mmHg/mm using vector flow mapping	through study completion, an average of 1 year	intraventricular pressure gradient from left ventricular apex to base
myocardial strain in % using two-dimension tissue tracking	through study completion, an average of 1 year	left ventricular longitudinal strain

Secondary Outcome Measures

Name	Time	Method
wall shear stress in pascal using vector flow mapping	through study completion, an average of 1 year	segmental wall shear stress of the left ventricle

Trial Locations

Locations (1)

Chengdu Sport University; 🇨🇳 Chengdu, Sichuan, China