The Antagonistic Effect of Plant Nutrients on Health Damage Caused by Environmental Pollutants
- Conditions
- InflammationIntestinal Functional Disorder
- Interventions
- Dietary Supplement: placeboDietary Supplement: Compound plant nutrients
- Registration Number
- NCT06437119
- Lead Sponsor
- Fudan University
- Brief Summary
The study attempts to conduct randomized controlled trials to understand whether daily exposure to environmental pollutants can cause harm to human health, explore whether the intake of plant nutritional supplements can alleviate potential health hazards caused by environmental pollutants, and provide scientific basis for the prevention and treatment of health hazards caused by environmental pollutant exposure.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 103
- Volunteers aged 18-65,
- BMI<35 kg/m2,
- agreed and signed an informed consent form.
- Suffering from known congenital or acquired immunodeficiency diseases, allergic diseases, gastrointestinal diseases, and other acute and chronic diseases that require treatment;
- Within one month before the experiment, use immunosuppressive drugs, antibiotics, probiotics, prebiotics, synthetic bacteria, or other drugs that are active in gastrointestinal motility;
- Consume nutritional supplements within one month before the experiment;
- Basic medical history (hypertension, diabetes); Having bad habits (smoking, drinking);
- Receive influenza vaccine within 12 months before the experiment;
- During pregnancy or lactation;
- Weight changes exceeding 5% within the three months prior to the experiment;
- Has been enrolled or planned to be enrolled in other studies.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description placebo group placebo A placebo with an indistinguishable appearance and color. 3 times a day, 1 pack at a time, dissolve in warm water and take with meals or after meals. Nutrition supplement group Compound plant nutrients The compound plant nutrients include extracts of licorice, sophora, wild cherry berry, dendrobium officinale, and pomegranate. They should be taken three times a day, one pack at a time, brewed and dissolved in warm water, and taken with meals or after meals.
- Primary Outcome Measures
Name Time Method PBMC single-cell sequencing analysis up to 2 months Fecal metagenomic sequencing up to 2 months MCP-1 up to 2 months ELISA detection of MCP-1 abundance in the blood of research subjects
IL-1β up to 2 months ELISA detection of IL-1β abundance in the blood of research subjects
Fecal microplastics (MPs) levels up to 2 months Py GC/MS method for detecting microplastic (MPs) levels in feces of research subjects.
IL-6 up to 2 months ELISA detection of IL-6 abundance in the blood of research subjects
TNF-α up to 2 months ELISA detection of TNF-α abundance in the blood of research subjects
- Secondary Outcome Measures
Name Time Method creatinine clearance rate up to 2 months Measure blood creatinine and urine creatinine, and calculate creatinine clearance rate based on this
White blood cell count (WBC) up to 1 months Determine White blood cell count (WBC) through blood routine examination
urine cast up to 2 months Determine urine cast through Urinalysis
Lymphocyte count up to 1 months Determine Lymphocyte count through blood routine examination
albumin up to 2 months Measuring plasma albumin content to evaluate liver function
total bilirubin up to 2 months Measuring total bilirubin to evaluate liver function
Red blood cell count (RBC) up to 1 months Determine Red blood cell count (RBC) through blood routine examination
urinary protein up to 2 months Determine urinary protein through Urinalysis
aspartate aminotransferase up to 2 months Measuring aspartate aminotransferase content to evaluate liver function
alanine aminotransferase up to 2 months Measuring aspartate aminotransferase content to evaluate liver function