PEEP VS ZEEP In cardiopulmonary resuscitation A randomised controlled pilot trial
试验速览
- 阶段
- 1/2 期
- 状态
- 尚未招募
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- To compare the rates to ROSC (return of spontaneous circulation) in patients receiving zero PEEP versus PEEP (5cm H2O) during CPR in cardiac arrest
研究概览
简要总结
This study is a randomised controlled pilot trial that aims to compare the difference in outcomes of patients with cardiac arrest receiving CPR with a PEEP of 5cm of H2O as against ZEEP ( PEEP of zero cm of H2O).Patients presenting to the emergency with cardiac arrest will be immediately shifted to the resuscitation area and CPR would be started; advanced airway would be secured.They would be randomised into control and intervention group after informed consent is obtained from the legally authorised representative and if they fulfil the inclusion criteria.CPR would be continued for a period of 40 minutes or till the achievement of ROSC; with blood samples taken at regular intervals for analysis.Primary outcome in this study is to compare the rates of ROSC between the control and intervention group. Secondary outcome aims to study the PCO2 clearance, ventilation related complications, 24 hour survival and neurological outcomes at discharge.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients with cardiac arrest 2.Legally authorised representative willing to give valid consent.
排除标准
- •1.Legally authorised representative unwilling to give consent 2.Patients less than 18 years of age 3.Patients requiring surgical airway 4.patients with obstructive airway disease 5.patients with history of trauma 6.pregnant women 7.patients with metastatic cancer.
结局指标
主要结局
To compare the rates to ROSC (return of spontaneous circulation) in patients receiving zero PEEP versus PEEP (5cm H2O) during CPR in cardiac arrest
时间窗: at achievement of ROSC or at maximum 40mins of CPR
次要结局
- 1.To compare the PCo2 clearance
- 2.Ventilation related complication(During the course of CPR)
- 3.24 hour survival rates(At 24 hours ( if applicable))
- Neurological outcomes(At discharge)
研究者
Dr Ashwin Kumar
AIIMS, New Delhi