Outcomes of a Novel Treatment Decision of Patients With Superficial Esophageal Carcinoma Synchronously Associated With Head and Neck Cancer
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- The first day of food intake of enrolled patients
研究概览
简要总结
To summarise the outcomes of a treatment decision of patients with superficial esophageal carcinoma synchronously associated with head and neck cancer, that is endoscopic treatment for the superficial esophageal carcinoma plus surgery of the head and neck carcinoma.
详细描述
As a same risk factor, such as heavy drinking and smoking, patients with head and ncek carcinoma are always suffering from synchronous esophageal squamous cell carcinoma. Previous studies illustrated that many patients with multiple esophageal lesions of early stage. In clinical practice, those patients are treated by extensive surgical resection of total pharyngo-laryngo-esophagectomy plus free jejunum interposition or gastric tube, then followed by chemoradiotherapy as standard treatment, resulting in a low quality of life for the patients, and due to the above mentioned disadvantages, many patients with synchronous superficial esophageal squamous cell carcinoma and head and neck carcinoma refused the surgery treatment. Our aims is to summarize the the outcomes of endoscopic treatment for the superficial esophageal carcinoma plus surgery of head and neck carcinoma.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with head and ncek carcinoma associated with synchronous superficial esophageal squamous cell carcinoma.
- •Patients agree to be treated with esophageal endoscopic submucosal dissection firstly, then accept surgery of head and neck carcinoma.
排除标准
- •Patients refuse a endoscopic submucosal dissection or surgery.
- •Patients with sever systemic disease, such as sever cardiopulmonary disease, renal failure and impaired blood coagulation.
- •Obstruction of the pharynx leading to a failure of insertion of endoscopy.
- •Patients with an advanced esophageal carcinoma evaluated by endoscopy.
结局指标
主要结局
The first day of food intake of enrolled patients
时间窗: An average of 1week
The first day of food intake after surgery of the head and neck carcinoma
次要结局
- The hospital stay of enrolled patients(An average of 1 month.)
- The relapse rate of the enrolled patients(an average of 2 years)
- The incidence of stenosis(an average of 2 years)
- The severity of stenosis(an average of 2 years)
研究者
Yanqing Li
professor, chief of gastrointestinal department of Qilu hospital of Shandong University
Shandong University