Osteopathic Manipulative Lymphatic Pump Technique and Its Effects to the Endocannabinoid System Activity as Measured by AEA Levels Via Mass Spectrometry and Mood Analogue Scale
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Anandamide
- Sponsor
- New York Institute of Technology
- Enrollment
- 2
- Locations
- 1
- Primary Endpoint
- Osteopathic Manipulative Lymphatic Pump Treatment and Its Relationship To Anandamide levels
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The Investigators will be studying the effects of Osteopathic Manipulative Lymphatic Pump Treatment on levels of anandamide in Saliva. A qualitative scale will also be used to measure the canabinomimetic effects of osteopathic treatment.
Detailed Description
The Endocannabinoid System is a signaling system composed of: 2 G-Protein coupled receptors (CB1 and CB2), substances acting on the cannabinoid receptors, and the enzymes and proteins involved in regulating endocannabinoids in tissue and at the receptors. The substances acting the cannabinoid receptors CB1 and CB2 are called endocannabinoids. The present study examines the effects of Osteopathic Manipulative Lymphatic Pump Techniques on levels of anandamide, an endocannabinoid, in saliva samples of adult subjects. Based on existing research, the investigators hypothesize that subjects who undergo osteopathic lymphatic treatment will have increased levels of anandamide. Establishing the levels of endocannabinoids in these subjects will allow for a direct measure of the efficacy of the Osteopathic Manipulative Lymphatic techniques. In addition to the quantification of endocannabinoid levels in saliva, a series of 16, 100 mm analog scales will be used to assess the cannabinomimetic effects in the subject pre and post OMM treatment/control and it will be correlated to changes in endocannabinoid levels.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Accepts healthy volunteers.
- •Able to read and understand scale for survey.
- •BMI (Body Mass Index) TBD- BMI between 18 and 25 kg/m2 Signed informed consent No exercising on the day of or day before the appointment Age 18 and above.
Exclusion Criteria
- •Neuropsychiatric disorders
- •Autoimmune Disorders
- •Unavailable 8AM-12PM
- •No Illicit drug use, including exogenous cannabis.
Outcomes
Primary Outcomes
Osteopathic Manipulative Lymphatic Pump Treatment and Its Relationship To Anandamide levels
Time Frame: 60 minutes
The Investigators will be studying the effects of Osteopathic Manipulative Lymphatic Pump Treatment on levels of anandamide in Saliva. A qualitative scale will also be used to measure the canabinomimetic effects of osteopathic treatment.