Effect of OMM on Anandamide Levels in Saliva

Not Applicable

Completed

• Conditions: Anandamide; Endocannabinoids
• Interventions: Other: Osteopathic Manipulative Medicine

• Registration Number: NCT02727023
• Lead Sponsor: New York Institute of Technology

Brief Summary

The Investigators will be studying the effects of Osteopathic Manipulative Lymphatic Pump Treatment on levels of anandamide in Saliva. A qualitative scale will also be used to measure the canabinomimetic effects of osteopathic treatment.

Detailed Description

The Endocannabinoid System is a signaling system composed of: 2 G-Protein coupled receptors (CB1 and CB2), substances acting on the cannabinoid receptors, and the enzymes and proteins involved in regulating endocannabinoids in tissue and at the receptors. The substances acting the cannabinoid receptors CB1 and CB2 are called endocannabinoids. The present study examines the effects of Osteopathic Manipulative Lymphatic Pump Techniques on levels of anandamide, an endocannabinoid, in saliva samples of adult subjects. Based on existing research, the investigators hypothesize that subjects who undergo osteopathic lymphatic treatment will have increased levels of anandamide. Establishing the levels of endocannabinoids in these subjects will allow for a direct measure of the efficacy of the Osteopathic Manipulative Lymphatic techniques. In addition to the quantification of endocannabinoid levels in saliva, a series of 16, 100 mm analog scales will be used to assess the cannabinomimetic effects in the subject pre and post OMM treatment/control and it will be correlated to changes in endocannabinoid levels.

Study Timeline

• Study Start: 2015-12
• Study First Submitted: 2016-01-19
• Study First Submitted QC: 2016-03-29
• Study First Posted: 2016-04-04
• Primary Completion: 2016-08
• Study Completion: 2017-09
• Status Verified: 2017-10
• Last Update Submitted: 2017-10-03
• Last Update Posted: 2017-10-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 2

Inclusion Criteria

• Accepts healthy volunteers.
• Able to read and understand scale for survey.
• BMI (Body Mass Index) TBD- BMI between 18 and 25 kg/m2 Signed informed consent No exercising on the day of or day before the appointment Age 18 and above.

Exclusion Criteria

• smoker
• Neuropsychiatric disorders
• Autoimmune Disorders
• Unavailable 8AM-12PM
• No Illicit drug use, including exogenous cannabis.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Osteopathic Manipulative Medicine	Osteopathic Manipulative Medicine	The thoracic inlet release, The Miller Thoracic Pump, Pedal Pump will be performed. These techniques are gentle and would be rhythmic in motion.

Primary Outcome Measures

Name	Time	Method
Osteopathic Manipulative Lymphatic Pump Treatment and Its Relationship To Anandamide levels	60 minutes	The Investigators will be studying the effects of Osteopathic Manipulative Lymphatic Pump Treatment on levels of anandamide in Saliva. A qualitative scale will also be used to measure the canabinomimetic effects of osteopathic treatment.

Trial Locations

Locations (1)

NYITCOM; 🇺🇸 Old Westbury, New York, United States