The Efficacy of Oral Versus Intravenous Hypertonic Saline Administration in Runners With Exercise-Associated Hyponatremia
Not Applicable
- Conditions
- Exercise-associated Hyponatremia
- Interventions
- Other: Intravenous hypertonic SalineOther: Oral hypertonic saline
- Registration Number
- NCT01110655
- Lead Sponsor
- Western States Endurance Run Research Foundation
- Brief Summary
The purpose of the study is to 1) evaluate incidence and primary cause of exercise-associated Hyponatremia (EAH) in race finishers participating in the Western States 100-mile Endurance Run, 2) determine if the ingestion of oral hypertonic saline (high salt) is as effective as intravenous administration of hypertonic saline to elevate below-normal blood salt concentrations (EAH) at the end of the Western States Endurance Run, and 3) determine if oral and intravenous hypertonic saline solutions are equally as effective at reversing mild (without altered mental status) symptoms associated with EAH.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- consenting Western States 100 race finisher
- hyponatremic
Exclusion Criteria
- altered mental status
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Intravenous hypertonic saline Intravenous hypertonic Saline - Oral hypertonic saline Oral hypertonic saline -
- Primary Outcome Measures
Name Time Method Blood sodium concentration post administration of oral or IV hypertonic saline. 1 hour post administration of hypertonic saline
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Western States Endurance Run
🇺🇸Sacramento, California, United States