The Efficacy of Oral Versus Intravenous Hypertonic Saline Administration in Runners With Exercise-Associated Hyponatremia

Not Applicable

• Conditions: Exercise-associated Hyponatremia

• Registration Number: NCT01110655
• Lead Sponsor: Western States Endurance Run Research Foundation

Brief Summary

The purpose of the study is to 1) evaluate incidence and primary cause of exercise-associated Hyponatremia (EAH) in race finishers participating in the Western States 100-mile Endurance Run, 2) determine if the ingestion of oral hypertonic saline (high salt) is as effective as intravenous administration of hypertonic saline to elevate below-normal blood salt concentrations (EAH) at the end of the Western States Endurance Run, and 3) determine if oral and intravenous hypertonic saline solutions are equally as effective at reversing mild (without altered mental status) symptoms associated with EAH.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-06
• Status Verified: 2010-04
• Study First Submitted: 2010-04-23
• Study First Submitted QC: 2010-04-23
• Last Update Submitted: 2010-04-23
• Study First Posted: 2010-04-26
• Last Update Posted: 2010-04-26
• Primary Completion: 2010-06
• Study Completion: 2010-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• consenting Western States 100 race finisher
• hyponatremic

Exclusion Criteria

• altered mental status

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Blood sodium concentration post administration of oral or IV hypertonic saline.	1 hour post administration of hypertonic saline

Trial Locations

Locations (1)

Western States Endurance Run; 🇺🇸 Sacramento, California, United States