NCT00429988已完成不适用
Ductal Lavage to Monitor and Treat High Risk Women
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Average number of atypical cells per ductal lavage sample
研究概览
简要总结
RATIONALE: Collecting samples of fluid using ductal lavage and nipple aspiration from participants at high risk for breast cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
PURPOSE: This clinical trial is using ductal lavage to collect fluid from women at high risk for breast cancer.
详细描述
OBJECTIVES:
Primary
- Determine the volume of atypical cells collected from ductal lavage in women at increased risk for breast cancer.
Secondary
- Determine assay techniques to analyze nipple aspirate fluid and ductal lavage fluid samples from these participants.
- Analyze the nipple aspirate fluid from these participants for specific and global protein signatures.
- Determine the replicability of markers in serial assays of these participants.
- Determine the percentage of participants with atypia on ductal lavage in which ductal lesions can be identified using ductoscopy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Average number of atypical cells per ductal lavage sample
次要结局
- Assay techniques development for nipple aspirate fluid and ductal lavage fluid analysis
- Specific and global protein signature analysis of nipple aspirate
- Replicability of markers in serial assays
- Percentage of participants with atypia on ductal lavage in which ductal lesions can be identified using ductoscopy
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Nipple Aspiration, Ductal Lavage, and Duct Endoscopy in Screening Women at Moderate-to-High Risk of Developing Breast CancerBreast CancerNCT00081003Royal Marsden NHS Foundation Trust1,000
Unknown
2 期
Nipple Aspiration, Ductal Lavage, and Duct Endoscopy For Diagnostic Assessment in Women Undergoing Surgery for Breast CancerBreast CancerNCT00083018Royal Marsden NHS Foundation Trust100
已完成
不适用
Protocol for Postmenopausal Women at Increased Risk of Developing Breast CancerBreast CancerNCT00291083Carol Fabian, MD229
已完成
不适用
Clinical Evaluation of the SEQureDx T21 Test In High Risk PregnanciesDown SyndromeFetal AneuploidyNCT01555346Sequenom, Inc.3,062
已完成
不适用
Tissue Samples and Bodily Fluid Specimens BankingEndocrine Disorders of Female Reproductive SystemNCT02431884University of Tennessee200