Exploration of Neurophysiological Mechanisms of Exercise-Induced Hypoalgesia With Blood Flow Restriction in Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- PPT
研究概览
简要总结
This experimental study explores the neurophysiological mechanisms associated with pain modulation following a single session of low-intensity resistance exercise combined with BFR in healthy young adults. The study evaluates changes in sensory thresholds before and after the intervention using validated quantitative sensory testing (QST) methods. These include pressure pain thresholds, conditioned pain modulation, thermal thresholds, and temporal summation. The findings may contribute to a better understanding of the role of the nervous system in exercise-induced hypoalgesia, particularly in response to BFR protocols, with implications for future research in pain and rehabilitation.
详细描述
Exercise-induced hypoalgesia (EIH) is a physiological response characterized by reduced pain sensitivity following physical activity. Several central and peripheral mechanisms have been proposed to explain EIH, including activation of descending inhibitory pathways and peripheral nociceptor modulation. BFR training involves the application of controlled vascular occlusion during low-load exercise and has shown promising results in enhancing both muscle function and pain modulation.
This is a single-arm, pre-post experimental study involving healthy adults aged 18-35 years. All participants undergo a single session of low-intensity resistance exercise involving the lower limbs, performed under 60% limb occlusion pressure. QST is performed before and immediately after the intervention, including:
Pressure Pain Thresholds (PPT) measured with a digital algometer
Conditioned Pain Modulation (CPM) using cold-water immersion
Thermal thresholds assessed with a computer-controlled thermode
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Asymptomatic at the time of evaluation.
- •Able to provide written informed consent.
- •Available to attend a single evaluation and intervention session at the research center.
排除标准
- •Bilateral knee symptoms or suspected patellar tendinopathy.
- •Increased symptoms with dynamic loading.
- •Neurological disorders.
- •Inflammatory rheumatic diseases.
- •Cardiac diseases.
- •Any surgery within the last 3 months.
- •Pregnancy.
- •Alcohol consumption on the day of participation.
- •Hypertension (systolic blood pressure ≥140 mmHg).
- •History of deep vein thrombosis.
- •History of endothelial dysfunction.
- •Peripheral vascular disease.
- •Diabetes.
- •Active infection.
- •Spinal or referred pain.
- •Previous experience with blood flow restriction (BFR) training.
- •Overweight or obesity.
研究组 & 干预措施
Single Group - Low-Intensity Resistance Training with BFR
A single session of low-intensity resistance training combined with BFR applied to the proximal thigh of the dominant leg at 60% of total arterial occlusion pressure. Sensory and pain modulation assessments (PPT, CPM, TS, and thermal thresholds) performed immediately before and after the training session.
干预措施: Low-Intensity Resistance Training with BFR (Other)
结局指标
主要结局
PPT
时间窗: At baseline and immediately after the intervention session.
Change in PPT will be assessed using a digital algometer (1 cm² round tip) applied perpendicularly to the skin at a rate of 1 kg/s until pain is first perceived. Three measurements will be averaged for each site. Measurement sites include the medial joint line of the dominant knee and the dorsal forearm contralateral to the knee. Each measurement will be performed at 30-second intervals.
CPM
时间窗: Baseline (before intervention) and immediately after the intervention session.
Changes in CPM will be assessed by immersing the hand up to the wrist in a cold water bath (0.6-0.8°) with a circulating water pump.The dominant arm for healthy participants will be immersed in the cold-water bath. In general, the conditioning stimulus will be applied for 2 min or maximum tolerance (whichever comes first). A computerized, custom-made visual analog scale will be used to continuously track the response profile to conditional stimuli across participants during the application of CPM. A numeric rating scale ranging from 0 to 100, where 0 represents no perception, 30 represents pain threshold (defined as the time to reach a painful sensation at the predefined stimulation intensity) and 100 represents the tolerance threshold (defined as the sensation of pain when becomes intolerable). Before and immediately after the immersion, PPT measurements will be assessed on medial joint line of the dominant knee and dorsal forearm contralateral to the knee.
PPT
时间窗: At baseline and immediately after the intervention session.
Change in PPT will be assessed using a digital algometer (1 cm² round tip) applied perpendicularly to the skin at a rate of 1 kg/s until pain is first perceived. Three measurements will be averaged for each site. Measurement sites include the medial joint line of the dominant knee and the dorsal forearm contralateral to the knee. Each measurement will be performed at 30-second intervals.
次要结局
- Thermal sensitivity thresholds(Immediately before and immediately after the intervention session.)
- TS Score(Immediately before and immediately after the intervention session.)
- Thermal sensitivity thresholds(Immediately before and immediately after the intervention session.)
- TS Score(Immediately before and immediately after the intervention session.)
研究者
Leonardo Intelangelo
Director
University of Gran Rosario