Prospective Cohort Study on Epstein-Barr Virus Antibody and Cancer Risks
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100,000
- 试验地点
- 2
- 主要终点
- Cancer incidence
研究概览
简要总结
The goal of this prospective cohort study is to investigate the associations between Epstein-Barr Virus (EBV) antibody levels and the risk of overall and site-specific cancer types in Southern China. The main questions it aims to answer are:
Question 1: In addition to the established EBV-associated cancer types, such as lymphomas, nasopharyngeal carcinoma, and stomach cancer, whether EBV is associated with other cancer types? Question 2: What's the cancer burden attributed to EBV in Southern China?
详细描述
Growing molecular evidence suggests the involvement of EBV in various cancers, however, comprehensive epidemiological evidence is still lacking. In this study, researchers conducted a population-based prospective cohort study to investigate the associations between EBV antibodies and the risk of overall and site-specific cancer types in Southern China. All the participants underwent EBV antibody tests at enrollment and were subsequently followed up annually for cancer incidence, vital status, and immigration status. The primary objective of this study was to provide prospective evidence for the role of EBV in multiple cancers, shedding light on the etiology of a broad range of common EBV-associated cancers.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 69 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subject residents in Zhongshan or Wuzhou City;
- •Subject has no medical record of prevalent cancer;
- •Subject has psychical condition and well consciousness, and willingness to accept and cooperate with the study's follow-up procedures.
排除标准
- •Subject has heavy cardiovascular, liver, or kidney disease;
- •Subject has prevalent cancer.
结局指标
主要结局
Cancer incidence
时间窗: 10 years
The primary outcome of the study was the diagnosis of any type of cancer. The cancer type for each participant was defined as their initial and primary cancer diagnosis.
次要结局
- All-cause mortality(10 years)
研究者
Jia wei-hua
Professor
Sun Yat-sen University