The Effect of Resistance Training and Aerobic Training on Body Composition During Chemotherapy
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- Changes in body composition
研究概览
简要总结
Chemotherapy can induce muscle loss in colorectal, breast and advanced renal cell carcinoma patients. The Danish nation-wide training and rehabilitation offer 'Body & Cancer' offers intensive resistance and endurance training to all Danish cancer patients receiving chemotherapy with the aim of reducing treatment-related fatigue and physical impairments, but the potential of the training to preserve or improve muscle mass is uninvestigated.
Furthermore, the underlying biological mechanisms of treatment and/or exercise induced changes in muscle mass in cancer patients remains uninvestigated.
Thus, the primary purpose of the present study is to investigate changes in body composition during chemotherapy and after resistance and aerobic training combined with protein supplementation during ongoing chemotherapy in cancer patients. Secondly, we aim to investigate the underlying biological mechanisms of muscle mass regulation in biopsies obtained before and after a control period as well as after 10 weeks of exercise, both during chemotherapy.
We hypothesize that 10 weeks exercise will improve muscle mass and body composition in cancer patients during chemotherapy as compared to a control period during chemotherapy alone.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Currently receiving curative, adjuvant, neo-adjuvant or palliative chemotherapy
- •No documented bone metastases or myelomatosis
- •No documented CNS affection
- •WHO performance status 0-1
- •No chronical thrombocytopenia or leukopenia
- •No physical conditions preventing exercise participation
- •No serious symptoms of heart disease
- •No dementia or mental illness preventing participation
- •Signed written concent
- •Age above 18 years
排除标准
- •Participation in systematic resistance training three months prior to inclusion
研究组 & 干预措施
Exercise & Chemotherapy
Following a control period during active chemotherapy the patients undergo ten weeks of supervised exercise comprised of resistance and aerobic training in combination with protein supplementation during ongoing chemotherapy.
干预措施: Exercise (Behavioral)
结局指标
主要结局
Changes in body composition
时间窗: Assessment before (baseline) and after (pre-training) the control period of 7 weeks (average), where patients recieve chemotherapy, and again after completion of 10 weeks of exericse (post-training).
Changes in lean body mass and fat mass wil be assessed using Dual Energy X-Ray Absorptiometry
次要结局
- Changes in underlying biological mechanisms associated with changes in muscle mass(Assessment before (baseline) and after (pre-training) the control period of 7 weeks (average), where patients recieve chemotherapy, and again after completion of 10 weeks of exericse (post-training).)
- Changes in aerobic performance(Assessment before (baseline) and after (pre-training) the control period of 7 weeks (average), where patients recieve chemotherapy, and again after completion of 10 weeks of exericse (post-training).)
- Changes in cancer related fatigue and quality of life(Assessment before (baseline) and after (pre-training) the control period of 7 weeks (average), where patients recieve chemotherapy, and again after completion of 10 weeks of exericse (post-training).)
- Changes in dynamic muscle strength(Assessment before (baseline) and after (pre-training) the control period of 7 weeks (average), where patients recieve chemotherapy, and again after completion of 10 weeks of exericse (post-training).)
- Changes in functional performance(Assessment before (baseline) and after (pre-training) the control period of 7 weeks (average), where patients recieve chemotherapy, and again after completion of 10 weeks of exericse (post-training).)
研究者
Simon Lønbro
M.Sc., PhD.
Department of Public Health, Denmark